Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.33 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.39 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL339826 | 0.96 | BBOX1 (0.41) | BBOX1EHMT2EHMT1ALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL30702244 | 0.92 | BBOX1 (0.39) | BBOX1EHMT2EHMT1ALDH1A1TDP1 | |
| SCHEMBL26417080 | 0.92 | BBOX1 (0.39) | BBOX1EHMT2EHMT1ALDH1A1TDP1 | |
| Benzene SCHEMBL27586265 | 0.92 | BBOX1 (0.39) | BBOX1EHMT2EHMT1ALDH1A1TDP1 | |
| SCHEMBL14523884 | 0.79 | TDP1 (0.35) | BBOX1EHMT2EHMT1ALDH1A1TDP1 | |
| SCHEMBL18827728 | 0.78 | ACHE (0.53) | ALDH1A1TDP1LMNAMEN1KMT2A | |
| SCHEMBL14599316 | 0.78 | CA12 (0.53) | ALDH1A1TDP1LMNAMEN1BLM | |
| SCHEMBL22173519 | 0.78 | BBOX1 (0.30) | BBOX1EHMT2EHMT1 | |
| Pyridine SCHEMBL28721033 | 0.78 | TSHR (0.50) | ALDH1A1TDP1LMNAMEN1BLM | |
| SCHEMBL28305721 | 0.78 | TSHR (0.53) | ALDH1A1TDP1MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996011196-A1 | PYRAZOLYLMETHYL-THIAZOLIDINES USEFUL AS HYPOGLYCEMIC AGENTS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1996-04-18 | — | — | WO | disclosed |