Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CETP | P11597 | 1/20 | 0.48 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.47 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.47 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.47 |
| ▸ | PTGES | O14684 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9079600 | 0.86 | LPAR1 (0.56) | KDM4EALDH1A1LPAR1LPAR5PTGES | |
| SCHEMBL9081179 | 0.85 | PTGES (0.59) | MEP1BMEP1ANR3C1LPAR1LPAR5 | |
| SCHEMBL9081212 | 0.84 | LPAR1 (0.49) | KDM4EALDH1A1LPAR1LPAR5PTGES | |
| SCHEMBL9082141 | 0.83 | LPAR1 (0.52) | KDM4EALDH1A1LPAR1LPAR5PTGES | |
| SCHEMBL9081177 | 0.83 | PTGES (0.50) | NR3C1LPAR1LPAR5PTGESACHE | |
| SCHEMBL9082353 | 0.83 | LPAR1 (0.59) | LPAR1LPAR5 | |
| SCHEMBL9081725 | 0.83 | ALDH1A1 (0.59) | KDM4EALDH1A1LPAR1LPAR5PTGES | |
| SCHEMBL10397250 | 0.81 | MAPT (0.61) | KDM4EALDH1A1NR3C1MAPTRAB9A | |
| SCHEMBL15392053 | 0.81 | MAPT (0.61) | KDM4EALDH1A1NR3C1MAPTRAB9A | |
| SCHEMBL9080500 | 0.81 | LPAR1 (0.52) | KDM4EALDH1A1LPAR1LPAR5PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996034851-A1 | BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |