Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 6/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8813027 | 1.00 | LCK (0.50) | LCKMAPK1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL8812551 | 0.81 | KMT2A (0.49) | ALDH1A1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL9080585 | 0.81 | KMT2A (0.49) | ALDH1A1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL30711612 | 0.76 | LCK (0.67) | LCKMAPK1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4504096 | 0.76 | LCK (0.67) | LCKMAPK1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL50044 | 0.74 | LCK (0.60) | LCKMAPK1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL8809685 | 0.71 | RAB9A (0.50) | ALDH1A1SMN1; SMN2GAAPKMDHODH | |
| SCHEMBL9080024 | 0.71 | RAB9A (0.50) | ALDH1A1SMN1; SMN2GAAPKMDHODH | |
| SCHEMBL12202668 | 0.71 | DHODH (0.72) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL13531076 | 0.71 | DHODH (0.72) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532259-A | ANTITUMOR | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-02 | — | — | US | disclosed |
| US-5494911-A | TREATING LEUKEMIA, SARCOMA, CARCINOMA, LYMPHOMA, SKIN CANCER | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-02-27 | — | — | US | disclosed |