Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.50 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809685 | 1.00 | RAB9A (0.50) | RAB9ANPC1MAPTSMN1; SMN2POLB | |
| SCHEMBL6374526 | 0.79 | MAPT (0.53) | RAB9ANPC1MAPTSMN1; SMN2POLB | |
| SCHEMBL8813784 | 0.78 | SMN1; SMN2 (0.60) | MAPTSMN1; SMN2POLBALDH1A1PKM | |
| SCHEMBL9081508 | 0.78 | SMN1; SMN2 (0.60) | MAPTSMN1; SMN2POLBALDH1A1PKM | |
| SCHEMBL11225467 | 0.78 | MAPT (0.62) | RAB9ANPC1MAPTSMN1; SMN2POLB | |
| SCHEMBL9345674 | 0.77 | MAPT (0.50) | RAB9ANPC1MAPTSMN1; SMN2POLB | |
| SCHEMBL9345666 | 0.77 | MAPT (0.50) | RAB9ANPC1MAPTSMN1; SMN2POLB | |
| SCHEMBL9525592 | 0.76 | MRE11 (0.52) | MAPTSMN1; SMN2ALDH1A1DHODHKDM4E | |
| SCHEMBL9781555 | 0.76 | MRE11 (0.52) | MAPTSMN1; SMN2ALDH1A1DHODHKDM4E | |
| SCHEMBL1691061 | 0.76 | MAPT (0.68) | RAB9ANPC1MAPTSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532259-A | ANTITUMOR | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-02 | — | — | US | disclosed |
| US-5494911-A | TREATING LEUKEMIA, SARCOMA, CARCINOMA, LYMPHOMA, SKIN CANCER | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-02-27 | — | — | US | disclosed |