Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.77 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.77 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.77 |
| ▸ | BCHE | P06276 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15131123 | 0.91 | ADRA1D (0.65) | ADRA1DADRA1AADRA1BBCHEKMT2A | |
| SCHEMBL7034334 | 0.87 | ADRA1D (1.00) | ADRA1DADRA1AADRA1BBCHEKMT2A | |
| SCHEMBL9082688 | 0.84 | ADRA1D (0.63) | ADRA1DADRA1AADRA1BPOLBALDH1A1 | |
| SCHEMBL9082667 | 0.84 | ADRA1D (0.73) | ADRA1DADRA1AADRA1BKMT2APOLB | |
| SCHEMBL1965727 | 0.84 | CHRM2 (0.60) | ADRA1DADRA1AADRA1BBCHEKMT2A | |
| SCHEMBL9081216 | 0.83 | ADRA1D (0.61) | ADRA1DADRA1AADRA1BALDH1A1GRIN2B | |
| SCHEMBL9082016 | 0.82 | ADRA1D (0.74) | ADRA1DADRA1AADRA1BALDH1A1GRIN1 | |
| SCHEMBL9084496 | 0.82 | ADRA1D (0.60) | ADRA1DADRA1AADRA1BCHRM2CHRM3 | |
| SCHEMBL9083412 | 0.82 | ADRA1D (0.70) | ADRA1DADRA1AADRA1BKMT2APOLB | |
| Hydrochloric Acid SCHEMBL7335860 | 0.80 | POLB (0.74) | KMT2APOLBCHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508306-A | USED FOR TREATMENT OF BENIGN PROSTATIC HYPERPLASIA, LOWERING INTRAOCULAR PRESSURE AND INHIBITING CHOLESTEROL SYNTHESIS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1996-04-16 | — | — | US | disclosed |
| WO-1995007075-A9 | NOVEL AROMATIC AMINE DERIVATIVES | — | 1995-04-27 | — | — | WO | disclosed |
| WO-1995007075-A1 | NOVEL AROMATIC AMINE DERIVATIVES | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1995-03-16 | — | — | WO | disclosed |