SCHEMBL9085486

SCHEMBL9085486

Clc1cc(N2CCCC2)nc(NC2CCCC2)n1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 6/20 0.56
PDE4A P27815 4/20 0.47
CHRM3 P20309 3/20 0.47
PDE4B Q07343 3/20 0.47
PDE4C Q08493 3/20 0.47
PDE4D Q08499 3/20 0.47
NUDT1 P36639 1/20 0.47
HTT P42858 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
NPSR1 Q6W5P4 1/20 0.45
MAPK1 P28482 2/20 0.41
CDC7 O00311 1/20 0.41
CHEK1 O14757 1/20 0.41
MAPK13 O15264 1/20 0.41
DAPK3 O43293 1/20 0.41
DYRK3 O43781 1/20 0.41
ROCK2 O75116 1/20 0.41
MAP4K4 O95819 1/20 0.41
NTRK1 P04629 1/20 0.41
PRKCG P05129 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9083695 0.92 HRH4 (0.49) HRH4NUDT1ROCK1PRKD2
SCHEMBL30605627 0.89 HRH4 (0.51) HRH4PDE4ACHRM3PDE4BPDE4C
SCHEMBL26604142 0.88 MAPK8 (0.52) HRH4PDE4ACHRM3PDE4BPDE4C
SCHEMBL30605615 0.84 HRH4 (0.50) HRH4PDE4AHTTSMN1; SMN2NPSR1
SCHEMBL30605611 0.83 HRH4 (0.45) HRH4PDE4AHTTSMN1; SMN2NPSR1
SCHEMBL26604121 0.82 HRH4 (0.51) HRH4RAF1BRAFMEN1ALDH1A1
SCHEMBL9085610 0.82 PDE4A (0.53) HRH4PDE4AMAPK1CDC7CHEK1
SCHEMBL30605621 0.81 CCNT1 (0.47) HRH4PDE4ACHRM3PDE4BPDE4C
SCHEMBL9085702 0.81 HRH4 (0.52) HRH4PDE4ACHRM3PDE4BPDE4C
SCHEMBL935515 0.80 PDE4A (0.56) PDE4ASMN1; SMN2MAPK1CDC7CHEK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5550240-A Piperazinyl-bis(alkylamino)pyrimidine derivatives and process for preparing same RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 1996-08-27 US disclosed
EP-0644885-A1 NOVEL BIOLOGICALLY ACTIVE EBURNAMENINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME RICHETER GEDEON VEGYESZETI GYAR RT. (HU) 1995-03-29 EP disclosed
WO-1993025550-A1 NOVEL BIOLOGICALLY ACTIVE EBURNAMENINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME RICHETER GEDEON VEGYÉSZETI GYÁR RT. (HU) 1993-12-23 WO disclosed