Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 5/20 | 0.71 |
| ▸ | TUBB | P07437 | 5/20 | 0.71 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.71 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.71 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.71 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.71 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.71 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.71 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.71 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.71 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.71 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.71 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.71 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.71 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.71 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.69 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11504708 | 0.91 | TUBB4A (0.69) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL28403764 | 0.87 | AKR1B1 (0.69) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4464142 | 0.84 | HTR2A (0.75) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL29079535 | 0.84 | AKR1B1 (0.70) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL18563074 | 0.84 | TUBB4A (0.78) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL663128 | 0.83 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9189942 | 0.83 | TUBB4A (0.73) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9184918 | 0.83 | TUBB1 (0.73) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL29349837 | 0.82 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL1535646 | 0.82 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5569786-A | ANTICARCINOGENIC AGENTS, LEUKEMIA | ARIZONA BOARD OF REGENTS ACTING ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 1996-10-29 | — | — | US | disclosed |
| US-5430062-A | Combretastatin analogues; inhibition of tubulin polymerization and colchicine binding; antitumor,-mitotic and -neoplastic agents | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5409953-A | Administering to treat lymphocytic leukemia | ARIZONA BOARD OF REGENTS ACTING ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 1995-04-25 | — | — | US | disclosed |
| EP-0641301-A1 | STILBENE DERIVATIVES AS ANTICANCER AGENTS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1993023357-A1 | STILBENE DERIVATIVES AS ANTICANCER AGENTS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| EP-0276051-B1 | ANTINEOPLASTIC COMPOUNDS | ARIZONA BOARD OF REGENTS (US) | 1991-08-21 | — | — | EP | disclosed |
| US-4996237-A | Tubulin polymerization inhibitor; antitumor agent; leukemia and colon cancer | ARIZONA BOARD OF REGENTS (US) | 1991-02-26 | — | — | US | disclosed |