Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28549232 | 0.85 | DCUN1D1 (0.39) | METAP2RAB9AMAPK1ALDH1A1LMNA | |
| SCHEMBL6693198 | 0.85 | DCUN1D1 (0.41) | METAP2RAB9AMAPK1ALDH1A1HPGD | |
| SCHEMBL2765284 | 0.81 | KMT2A (0.52) | METAP2METAP1NPC1RAB9AMEN1 | |
| SCHEMBL19186830 | 0.79 | KMT2A (0.50) | METAP2METAP1NPC1RAB9AMEN1 | |
| SCHEMBL11624680 | 0.77 | IDO1 (0.53) | METAP2NPC1RAB9AMAPK1TP53 | |
| SCHEMBL8036362 | 0.76 | LMNA (0.50) | SYKNPC1RAB9AMAPK1HPGDS | |
| SCHEMBL415 | 0.74 | NPC1 (0.40) | SYKNPC1RAB9AMAPK1HPGDS | |
| SCHEMBL27975582 | 0.72 | ALDH1A1 (0.51) | NPC1RAB9AMAPK1HPGDSTSHR | |
| SCHEMBL3294988 | 0.71 | LMNA (0.53) | NPC1RAB9AMAPK1TSHRMEN1 | |
| SCHEMBL29688196 | 0.71 | LMNA (0.53) | NPC1RAB9AMAPK1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583130-A | Benzo-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1996-12-10 | — | — | US | disclosed |
| WO-1994007486-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-04-14 | — | — | WO | disclosed |