Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.56 |
| ▸ | HTR2A | P28223 | 4/20 | 0.56 |
| ▸ | HTR7 | P34969 | 4/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | KRAS | P01116 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9092789 | 0.90 | HTR7 (0.43) | HTR2CHTR2AHTR7PRMT5 | |
| SCHEMBL7213168 | 0.84 | HTR2C (0.39) | HTR2CHTR2APRMT5 | |
| SCHEMBL9094869 | 0.78 | HTR2C (0.53) | HTR2CHTR2AHTR7PRMT5NTSR1 | |
| SCHEMBL9093685 | 0.76 | HTR2C (0.37) | HTR2CHTR2A | |
| SCHEMBL12474064 | 0.74 | HTR2C (0.77) | HTR2CHTR2AHTR7PRMT5NTSR1 | |
| SCHEMBL8959569 | 0.72 | HTR2C (0.72) | HTR2CHTR2AHTR7PRMT5NTSR1 | |
| SCHEMBL8959875 | 0.72 | HTR2C (1.00) | HTR2CHTR2AHTR7NTSR1 | |
| SCHEMBL4944251 | 0.72 | HTR2C (0.68) | HTR2CHTR2AHTR7PRMT5NTSR1 | |
| SCHEMBL9232987 | 0.72 | HTR2C (1.00) | HTR2CHTR2AHTR7NTSR1 | |
| SCHEMBL8959574 | 0.72 | HTR2C (0.72) | HTR2CHTR2AHTR7PRMT5NTSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532088-B1 | O-Heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroaryl macrolides | MERCK & CO INC (US) | 1996-12-04 | — | — | EP | disclosed |
| US-5352783-A | Treating autoimmune diseases | MERCK & CO., INC. (US) | 1994-10-04 | — | — | US | disclosed |
| US-5349061-A | O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity | MERCK & CO., INC. (US) | 1994-09-20 | — | — | US | disclosed |
| US-5310901-A | Autoimmune diseases; antiinflammatory agents; fungicides; prevention of organ transplant rejection; alkylation and/or arylation at C-42 | MERCK & CO., INC. (US) | 1994-05-10 | — | — | US | disclosed |
| US-5252732-A | D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity | MERCK & CO., INC. (US) | 1993-10-12 | — | — | US | disclosed |
| WO-1993005058-A1 | O-HETEROARYL, O-ALKYLHETEROARYL, O-ALKENYLHETEROARYL AND O-ALKYNYLHETEROARYLMACROLIDES | MERCK & CO., INC. (US) | 1993-03-18 | — | — | WO | disclosed |
| EP-0532088-A1 | O-Heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroaryl macrolides | MERCK & CO. INC. (US) | 1993-03-17 | — | — | EP | disclosed |