Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 9/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 8/20 | 0.46 |
| ▸ | EP300 | Q09472 | 2/20 | 0.39 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.38 |
| ▸ | TLR3 | O15455 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9092301 | 0.90 | HIF1A (0.48) | HIF1AEPAS1EP300COXFA4PTGS1 | |
| SCHEMBL9092543 | 0.79 | HIF1A (0.44) | HIF1AEPAS1EP300COXFA4TLR3 | |
| SCHEMBL9092213 | 0.72 | HIF1A (0.44) | HIF1AEPAS1EP300PTGS1PTGS2 | |
| SCHEMBL9092974 | 0.70 | HIF1A (0.46) | HIF1AEPAS1EP300 | |
| SCHEMBL9092249 | 0.69 | HIF1A (0.46) | HIF1AEPAS1EP300TLR3PTGS1 | |
| SCHEMBL9092059 | 0.69 | HIF1A (0.40) | HIF1AEPAS1EP300 | |
| SCHEMBL8290932 | 0.68 | NPC1 (0.46) | PTGS1PTGS2 | |
| SCHEMBL791815 | 0.68 | NPC1 (0.40) | PTGS2 | |
| SCHEMBL9090422 | 0.68 | HIF1A (0.45) | HIF1AEPAS1EP300 | |
| SCHEMBL8885575 | 0.65 | ALDH1A1 (0.40) | HIF1AEPAS1COXFA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5574049-A | POTASSIUM CHANNEL OPENERS, BRONCHODILATORS, ANTIASTHMA | SANDOZ LTD. (CH) | 1996-11-12 | — | — | US | disclosed |
| EP-0623129-A1 | 2,2-DIALKYL- AND 2,2-DIALKYL-3,4-DIHYDRO-3-HYDROXY-2H-1-BENZOPYR ANS, THEIR USE AS PHARMACEUTICALS | Novartis AG (CH) | 1994-11-09 | — | — | EP | disclosed |
| WO-1994012493-A1 | 2,2-DIALKYL- AND 2,2-DIALKYL-3,4-DIHYDRO-3-HYDROXY-2H-1-BENZOPYR ANS, THEIR USE AS PHARMACEUTICALS | SANDOZ, LTD. (CH) | 1994-06-09 | — | — | WO | disclosed |