Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 6/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9051319 | 0.85 | ALDH1A1 (0.47) | ALDH1A1POLBHTTHIF1AEPAS1 | |
| SCHEMBL9050508 | 0.83 | HIF1A (0.43) | ALDH1A1HTTHIF1AEPAS1HSD11B1 | |
| SCHEMBL8884017 | 0.83 | HIF1A (0.41) | ALDH1A1POLBHTTHIF1AEPAS1 | |
| SCHEMBL8886385 | 0.81 | HIF1A (0.42) | ALDH1A1HIF1AEPAS1KMT2AMEN1 | |
| SCHEMBL8886146 | 0.81 | HIF1A (0.40) | ALDH1A1POLBHTTHIF1AEPAS1 | |
| SCHEMBL8885347 | 0.80 | HIF1A (0.39) | ALDH1A1POLBHTTHIF1AEPAS1 | |
| SCHEMBL8884976 | 0.80 | HSD11B1 (0.39) | ALDH1A1POLBHIF1AEPAS1CYP1A2 | |
| SCHEMBL8884015 | 0.79 | HSD11B1 (0.39) | ALDH1A1POLBHTTHIF1AEPAS1 | |
| SCHEMBL8885663 | 0.79 | MAPK1 (0.45) | ALDH1A1HIF1AEPAS1KMT2AHSD11B1 | |
| SCHEMBL9050197 | 0.77 | HIF1A (0.39) | HIF1AEPAS1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5677324-A | MUSCLE RELAXANTS | PFIZER INC. (US) | 1997-10-14 | — | — | US | disclosed |
| EP-0690855-B1 | BENZOPYRANES AS POTASSIUM CHANNEL OPENERS | PFIZER LTD (GB) | 1996-12-18 | — | — | EP | disclosed |
| WO-1994020491-A1 | BENZOPYRANES AS POTASSIUM CHANNEL OPENERS | PFIZER LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |