Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.64 |
| ▸ | DRD2 | P14416 | 4/20 | 0.64 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | MC4R | P32245 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 3/20 | 0.45 |
| ▸ | DRD5 | P21918 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9095767 | 0.89 | DRD4 (0.56) | DRD4DRD2DRD3CHRM2CHRM4 | |
| SCHEMBL9095908 | 0.87 | DRD2 (0.62) | DRD4DRD2DRD3CHRM2CHRM4 | |
| SCHEMBL9097905 | 0.85 | DRD2 (0.62) | DRD4DRD2DRD3CHRM2CHRM4 | |
| SCHEMBL9096977 | 0.85 | DRD2 (0.65) | DRD4DRD2DRD3CHRM2CHRM4 | |
| SCHEMBL9096312 | 0.85 | DRD2 (0.62) | DRD4DRD2DRD3CHRM2CHRM4 | |
| SCHEMBL9096134 | 0.85 | DRD2 (0.62) | DRD4DRD2DRD3CHRM2CHRM4 | |
| SCHEMBL9094811 | 0.84 | DRD2 (0.56) | DRD4DRD2DRD3CHRM2CHRM4 | |
| SCHEMBL9097217 | 0.84 | DRD2 (0.58) | DRD4DRD2DRD3CHRM2CHRM4 | |
| SCHEMBL9096389 | 0.84 | DRD2 (0.83) | DRD4DRD2DRD3CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL9098451 | 0.84 | DRD4 (0.61) | DRD4DRD2DRD3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585378-A | Composition containing an oxoindole compound | AKTIEBOLAGET ASTRA (SE) | 1996-12-17 | — | — | US | disclosed |
| CN-1079464-A | Treatment comprises the preparation method of the valuable indolone of illness of cholinergic function reduction and the derivative of indole dione | ASTRA AB (SE) | 1993-12-15 | — | — | CN | disclosed |