Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 5/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9094675 | 0.85 | HTR6 (0.69) | HTR6PDK4BTKGRM5GRM1 | |
| SCHEMBL9094668 | 0.77 | HTR6 (0.62) | HTR6 | |
| SCHEMBL9094823 | 0.74 | PDK4 (0.51) | HTR6PDK4BTKGRM5GRM1 | |
| SCHEMBL9095527 | 0.73 | CNR1 (0.46) | HTR6PDK4BTKGRM5GRM1 | |
| SCHEMBL8026743 | 0.72 | HTR6 (0.67) | HTR6PDK4GRM5GRM1SCN9A | |
| SCHEMBL6133133 | 0.72 | HTR6 (0.51) | HTR6PDK4BTKGRM5GRM1 | |
| SCHEMBL9094666 | 0.71 | CNR1 (0.49) | HTR6PDK4BTKGRM5GRM1 | |
| SCHEMBL27007663 | 0.71 | GRM1 (0.55) | HTR6PDK4BTKGRM5GRM1 | |
| SCHEMBL31198982 | 0.70 | NAMPT (0.58) | HTR6PDK4BTKGRM5GRM1 | |
| SCHEMBL20740768 | 0.70 | HTR6 (0.43) | HTR6PDK4GRM5GRM1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0571471-B1 | 5-HETEROYL INDOLE DERIVATIVES | PFIZER (US) | 1996-03-06 | — | — | EP | disclosed |
| US-5409941-A | 5-heteroyl indole derivatives | PFIZER INC. (US) | 1995-04-25 | — | — | US | disclosed |
| WO-1992013856-A1 | 5-HETEROYL INDOLE DERIVATIVES | PFIZER INC. (US) | 1992-08-20 | — | — | WO | disclosed |