Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9095986 | 0.79 | CHRNA4 (0.37) | CHRNA4CHRNB2CHRM2CHRM1CHRM3 | |
| SCHEMBL12395706 | 0.78 | CHRNA4 (0.36) | CHRNA4CHRNB2CHRM2CHRM1CHRM3 | |
| SCHEMBL7530689 | 0.75 | CHRNA7 (0.36) | CHRNA4CHRNB2CHRM2CHRM1CHRM3 | |
| SCHEMBL21573624 | 0.75 | CHRNA7 (0.42) | CHRNA4CHRNB2CHRM2CHRM1CHRM3 | |
| SCHEMBL2607983 | 0.75 | CHRNA7 (0.42) | CHRNA4CHRNB2CHRM2CHRM1CHRM3 | |
| SCHEMBL14027182 | 0.75 | CHRNA7 (0.42) | CHRNA4CHRNB2CHRM2CHRM1CHRM3 | |
| SCHEMBL12663106 | 0.71 | CHRNA4 (0.40) | CHRNA4CHRNB2CHRM2CHRM1CHRM3 | |
| SCHEMBL9095797 | 0.71 | CHRM2 (0.54) | CHRNA4CHRNB2CHRM2CHRM1CHRM3 | |
| SCHEMBL3217728 | 0.71 | ALDH1A1 (0.40) | CHRNA4CHRNB2CHRM2CHRM1CHRM3 | |
| SCHEMBL12614403 | 0.71 | CHRM2 (0.43) | CHRM2CHRM1CYP2D6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9440976-B2 | 1,7-diazacarbazoles and methods of use | GENENTECH, INC. (US) | 2016-09-13 | — | — | US | disclosed |
| US-20150328195-A1 | 1,7-DIAZACARBAZOLES AND METHODS OF USE | GENENTECH, INC. (US) | 2015-11-19 | — | — | US | disclosed |
| US-20140171407-A1 | 1,7-DIAZACARBAZOLES AND METHODS OF USE | GENENTECH, INC. (US) | 2014-06-19 | — | — | US | disclosed |
| US-5508405-A | CHOLINERGIC AGENTS | BOEHRINGER INGELHEIM GMBH (DE) | 1996-04-16 | — | — | US | disclosed |
| US-5451587-A | 3-(2-PROPYNYLOXY)-1-AZABICYCLO(2.2.2)OCTANE FOR TREATING ALZHEIMER*S DISEASE | BOEHRINGER INGELHEIM GMBH (DE) | 1995-09-19 | — | — | US | disclosed |
| US-5286864-A | Deprotonation and salt formation with sodium hydride; alkylation, deprotecting | BOEHRINGER INGELHEIM KG (DE) | 1994-02-15 | — | — | US | disclosed |
| EP-0370415-B1 | QUINUCLIDINES, THEIR PHARMACEUTICAL USE AND PROCESS FOR THEIR PREPARATION | BOEHRINGER INGELHEIM KG (DE) | 1993-06-02 | — | — | EP | disclosed |
| EP-0370415-A1 | Quinuclidines, their pharmaceutical use and process for their preparation | BOEHRINGER INGELHEIM KG (DE) | 1990-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150328195-A1 | 1,7-DIAZACARBAZOLES AND METHODS OF USE | CHEK1, CHEK2, BUB1B | CHRNA4 3868/4885CHRNB2 3164/4885CHRM2 4407/4885 |
| US-20140171407-A1 | 1,7-DIAZACARBAZOLES AND METHODS OF USE | CHEK1, CHEK2, BUB1B | CHRNA4 3868/4885CHRNB2 3164/4885CHRM2 4407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.