Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9097754 | 0.85 | BACE1 (0.46) | MYCWDR5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL9099767 | 0.83 | BACE1 (0.46) | MYCWDR5TYMSPIK3CDPIK3CA | |
| SCHEMBL9097135 | 0.79 | NCF1 (0.41) | MYCWDR5BACE1KDM4E | |
| SCHEMBL28443457 | 0.70 | SMN1; SMN2 (0.45) | MYCWDR5TYMSKDM4ELMNA | |
| SCHEMBL9099215 | 0.69 | HPGD (0.54) | MYCWDR5KDM4ELMNAPOLB | |
| SCHEMBL9099400 | 0.69 | MYC (0.37) | MYCWDR5KDM4ELMNA | |
| SCHEMBL702948 | 0.67 | — | — | |
| SCHEMBL9098198 | 0.67 | MYC (0.59) | MYCWDR5BACE1POLBCDK2 | |
| SCHEMBL5171580 | 0.67 | CYP3A4 (0.48) | MYCWDR5CDK2NOS1 | |
| SCHEMBL1913966 | 0.64 | KCNH2 (0.64) | PIK3CDPIK3CAPIK3CBPI4KAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996030370-A2 | THIAZOLE AND THIADIAZOLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS USEFUL IN THE TREATMENT OF THROMBOCYTOPENIA | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-03 | — | — | WO | disclosed |