Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 9/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9099106 | 1.00 | SIGMAR1 (0.42) | SIGMAR1EPHX1EPHX2KMT2AMEN1 | |
| SCHEMBL27980206 | 0.79 | EPHX1 (0.49) | EPHX1EPHX2SMN1; SMN2NAAA | |
| SCHEMBL5698790 | 0.79 | CA2 (0.48) | — | |
| SCHEMBL76197 | 0.79 | CA2 (0.48) | — | |
| SCHEMBL8374553 | 0.79 | CA2 (0.48) | — | |
| SCHEMBL10964155 | 0.79 | CA2 (0.48) | — | |
| SCHEMBL8320113 | 0.79 | CA2 (0.48) | — | |
| SCHEMBL8324703 | 0.79 | CA2 (0.48) | — | |
| SCHEMBL77006 | 0.79 | CA2 (0.48) | — | |
| SCHEMBL27499209 | 0.79 | CA2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5498786-A | Synthesis of intermediates in the preparation of ACAT inhibitors | PFIZER INC. (US) | 1996-03-12 | — | — | US | claimed |
| WO-1992013843-A1 | SYNTHESIS OF INTERMEDIATES IN THE PREPARATION OF ACAT INHIBITORS | PFIZER INC. (US) | 1992-08-20 | — | — | WO | claimed |
| US-5498786-A | Synthesis of intermediates in the preparation of ACAT inhibitors | PFIZER INC. (US) | 1996-03-12 | — | — | US | disclosed |
| WO-1992013843-A1 | SYNTHESIS OF INTERMEDIATES IN THE PREPARATION OF ACAT INHIBITORS | PFIZER INC. (US) | 1992-08-20 | — | — | WO | disclosed |