Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7548702 | 1.00 | ALDH1A1 (0.41) | ALDH1A1TDP1CA2CYP2C19MMP1 | |
| SCHEMBL20087854 | 0.85 | ALDH1A1 (0.42) | ALDH1A1TDP1CA2CYP2C19 | |
| SCHEMBL7548122 | 0.76 | GRIK1 (0.35) | ALDH1A1TDP1CA2 | |
| SCHEMBL9408173 | 0.76 | ALDH1A1 (0.46) | ALDH1A1TDP1 | |
| SCHEMBL5109759 | 0.76 | ALDH1A1 (0.35) | ALDH1A1TDP1 | |
| SCHEMBL7544283 | 0.73 | FFAR3 (0.32) | ALDH1A1TDP1 | |
| SCHEMBL6263184 | 0.72 | HDAC3 (0.39) | ALDH1A1 | |
| SCHEMBL6263180 | 0.72 | HDAC3 (0.39) | ALDH1A1 | |
| SCHEMBL16469 | 0.71 | ALDH1A1 (0.41) | ALDH1A1TDP1CA2CYP2C19MMP1 | |
| SCHEMBL7547018 | 0.71 | CES1 (0.34) | ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609371-B1 | THIENOPYRAZINE-2,3-DIONES USEFUL FOR TREATING CNS DISORDERS, AND THEIR PREPARATION. | NOVO NORDISK AS (DK) | 1996-04-24 | — | — | EP | disclosed |
| EP-0609371-A1 | THIENOPYRAZINE-2,3-DIONES AND THEIR PREPARATION AND USE. | NOVO NORDISK AS (DK) | 1994-08-10 | — | — | EP | disclosed |
| US-5284847-A | Neurological and psychological disorders; antagonist at the glycine binding site on the N-methyl-D-aspartate receptor complex | NOVO NORDISK A/S (DK) | 1994-02-08 | — | — | US | disclosed |
| WO-1993008197-A1 | THIENOPYRAZINE-2,3-DIONES AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-04-29 | — | — | WO | disclosed |