⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9181967 | 0.77 | — | — | |
| SCHEMBL27935304 | 0.74 | ALOX15 (0.43) | — | |
| SCHEMBL8648313 | 0.73 | ALDH1A1 (0.34) | — | |
| SCHEMBL28321477 | 0.72 | — | — | |
| SCHEMBL7648067 | 0.72 | — | — | |
| SCHEMBL27609772 | 0.71 | — | — | |
| SCHEMBL9101342 | 0.70 | — | — | |
| SCHEMBL31396169 | 0.70 | — | — | |
| SCHEMBL28216682 | 0.68 | — | — | |
| SCHEMBL7189469 | 0.68 | ALOX15 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0701560-A1 | BICYCLIC ETHER DERIVATIVES AND THEIR USE AS 5-LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1996-03-20 | — | — | EP | disclosed |
| WO-1995030668-A1 | CYCLIC ETHER DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | ZENECA LIMITED (GB) | 1995-11-16 | — | — | WO | disclosed |
| US-5420298-A | Antiinflammatory agents by inhibition of leukotrienes | ZENECA LIMITED (GB) | 1995-05-30 | — | — | US | disclosed |
| WO-1994027999-A1 | BICYCLIC ETHER DERIVATIVES AND THEIR USE AS 5-LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1994-12-08 | — | — | WO | disclosed |
| EP-0586229-A1 | 3-Hydroxy-3-(subst-akyl)-pyrrolidines as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1994-03-09 | — | — | EP | disclosed |
| EP-0581464-A1 | Ester derivatives and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 1994-02-02 | — | — | EP | disclosed |