Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.86 |
| ▸ | LMNA | P02545 | 2/20 | 0.86 |
| ▸ | ESR1 | P03372 | 13/20 | 0.83 |
| ▸ | ESRRG | P62508 | 12/20 | 0.83 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | PGR | P06401 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | ESRRA | P11474 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | EGFR | P00533 | 1/20 | 0.65 |
| ▸ | GBA1 | P04062 | 1/20 | 0.65 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9097522 | 1.00 | HTR6 (0.86) | HTR6LMNAESR1ESRRGESR2 | |
| SCHEMBL9097517 | 1.00 | HTR6 (0.86) | HTR6LMNAESR1ESRRGESR2 | |
| SCHEMBL9097277 | 0.99 | HTR6 (0.84) | HTR6LMNAESR1ESRRGESR2 | |
| SCHEMBL9097271 | 0.99 | HTR6 (0.84) | HTR6LMNAESR1ESRRGESR2 | |
| Toremifene SCHEMBL906278 | 0.93 | HTR6 (1.00) | HTR6LMNAESR1ESRRGESR2 | |
| Toremifene SCHEMBL7465 | 0.93 | HTR6 (1.00) | HTR6LMNAESR1ESRRGESR2 | |
| Toremifene SCHEMBL1152000 | 0.93 | HTR6 (1.00) | HTR6LMNAESR1ESRRGESR2 | |
| Toremifene SCHEMBL2223880 | 0.92 | HTR6 (0.97) | HTR6LMNAESR1ESRRGESR2 | |
| 4-Hydroxytormifene SCHEMBL906309 | 0.91 | ESR1 (1.00) | HTR6LMNAESR1ESRRGESR2 | |
| 4-Hydroxytormifene SCHEMBL9099337 | 0.91 | ESR1 (1.00) | HTR6LMNAESR1ESRRGESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5491173-A | ESTROGENIC, ANTIESTROGENIC AGENTS, ANTITUMOR AGENTS | ORION-YHTYMA OY (FI) | 1996-02-13 | — | — | US | disclosed |