Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | KDM4C | Q9H3R0 | 7/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE9A | O76083 | 4/20 | 0.41 |
| ▸ | KDM5A | P29375 | 2/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | LATS1 | O95835 | 1/20 | 0.39 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12102095 | 0.78 | PARP1 (0.61) | KDM4EALDH1A1KDM4CPARP1PDE5A | |
| SCHEMBL26017637 | 0.71 | KDM4C (0.46) | ALDH1A1KDM4CPARP1PDE5AKDM5A | |
| SCHEMBL11783377 | 0.71 | KDM4C (0.55) | ALDH1A1KDM4CPARP1PDE5AKDM5A | |
| SCHEMBL26694443 | 0.71 | KDM4C (0.55) | ALDH1A1KDM4CPARP1PDE5AKDM5A | |
| SCHEMBL20299026 | 0.69 | HPGD (0.71) | ALDH1A1KDM4CPARP1PDE5APDE10A | |
| SCHEMBL6514859 | 0.69 | KDM4C (0.78) | ALDH1A1KDM4CPARP1PDE5APDE10A | |
| SCHEMBL30837976 | 0.69 | ALDH1A1 (0.56) | KDM4EALDH1A1PARP1PDE5A | |
| SCHEMBL14344516 | 0.68 | KDM4C (0.80) | KDM4EALDH1A1KDM4CPARP1PDE5A | |
| SCHEMBL10267532 | 0.68 | LATS1 (0.51) | JAK2LATS1LATS2 | |
| SCHEMBL21072845 | 0.68 | KDM4E (0.54) | KDM4EALDH1A1KDM4CPARP1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459558-A2 | COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS | IRM LLC (BM) | 2012-06-06 | — | — | EP | disclosed |