Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.80 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | HPGD | P15428 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.69 |
| ▸ | TNKS | O95271 | 10/20 | 0.68 |
| ▸ | TNKS2 | Q9H2K2 | 10/20 | 0.68 |
| ▸ | PARP1 | P09874 | 5/20 | 0.68 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.64 |
| ▸ | PDE5A | O76074 | 1/20 | 0.56 |
| ▸ | GUSB | P08236 | 4/20 | 0.55 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.55 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | WNT3A | P56704 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20299026 | 0.92 | HPGD (0.71) | KDM4CMAPTHPGDALDH1A1ALOX15 | |
| SCHEMBL14344501 | 0.89 | KDM4C (1.00) | KDM4CMAPTHPGDALDH1A1ALOX15 | |
| SCHEMBL15775258 | 0.86 | TNKS (0.67) | KDM4CMAPTHPGDALDH1A1ALOX15 | |
| SCHEMBL15775259 | 0.86 | TNKS (0.67) | KDM4CMAPTHPGDALDH1A1ALOX15 | |
| SCHEMBL29831923 | 0.82 | HPGD (1.00) | KDM4CMAPTHPGDALDH1A1ALOX15 | |
| SCHEMBL3460177 | 0.82 | HPGD (1.00) | KDM4CMAPTHPGDALDH1A1ALOX15 | |
| SCHEMBL259622 | 0.81 | KDM4C (0.55) | KDM4CMAPTHPGDTNKSTNKS2 | |
| SCHEMBL7280833 | 0.81 | HPGD (1.00) | KDM4CMAPTHPGDALDH1A1ALOX15 | |
| SCHEMBL29592833 | 0.81 | TNKS (1.00) | KDM4CMAPTHPGDALDH1A1ALOX15 | |
| SCHEMBL258433 | 0.81 | TNKS (1.00) | KDM4CMAPTHPGDALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |
| US-20070293500-A1 | QUINAZOLINE DERIVATIVES AS MEDICAMENTS | SCIOS, INC. | 2007-12-20 | — | — | US | disclosed |
| US-20070293500-A1 | QUINAZOLINE DERIVATIVES AS MEDICAMENTS | SCIOS, INC. | 2007-12-20 | — | — | US | disclosed |
| US-7232824-B2 | Quinazoline derivatives as medicaments | SCIOS, INC. (US) | 2007-06-19 | — | — | US | disclosed |
| US-7232824-B2 | Quinazoline derivatives as medicaments | SCIOS, INC. (US) | 2007-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293500-A1 | QUINAZOLINE DERIVATIVES AS MEDICAMENTS | SMAD3, SMAD2, TGFB2 | KDM4C 3469/4885MAPT 1601/4885HPGD 526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.