Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | STAT3 | P40763 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9103055 | 0.94 | LMNA (0.44) | MAPTKDM4ENPSR1NPC1ALDH1A1 | |
| SCHEMBL9102033 | 0.91 | LCLAT1 (0.42) | MAPTKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL9103475 | 0.89 | RAF1 (0.37) | MAPTKDRTP53PLK1 | |
| SCHEMBL4476005 | 0.88 | RAF1 (0.45) | MAPTKDM4ENPSR1NPC1ALDH1A1 | |
| SCHEMBL9104786 | 0.86 | RAF1 (0.49) | MAPTKDM4ENPSR1LMNAMAPK1 | |
| SCHEMBL9100193 | 0.84 | CDK8 (0.42) | LMNAKMT2AMEN1MAPK1KDR | |
| SCHEMBL9103507 | 0.83 | KMT2A (0.43) | MAPTKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL9102040 | 0.83 | CDK8 (0.45) | MAPTNPC1LMNASMN1; SMN2KMT2A | |
| SCHEMBL9103895 | 0.82 | KDR (0.37) | MAPTKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL4463605 | 0.82 | LMNA (0.46) | MAPTKDM4ENPSR1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685125-B1 | Pyrrole derivatives useful for the treatment of proliferative diseases | MERCK PATENT GMBH (DE) | 2012-06-06 | — | — | EP | claimed |
| EP-1685125-B1 | Pyrrole derivatives useful for the treatment of proliferative diseases | MERCK PATENT GMBH (DE) | 2012-06-06 | — | — | EP | disclosed |