Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.42 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9103507 | 0.92 | KMT2A (0.43) | DDR2KMT2AMEN1NPC1MAPK1 | |
| SCHEMBL9102036 | 0.91 | MAPT (0.41) | KMT2AMEN1NPC1MAPK1HPGD | |
| SCHEMBL9103055 | 0.89 | LMNA (0.44) | KMT2AMEN1NPC1HPGDHSD17B10 | |
| SCHEMBL9104786 | 0.89 | RAF1 (0.49) | MAPK1KDM4EL3MBTL1MAPTLMNA | |
| SCHEMBL9103895 | 0.89 | KDR (0.37) | DDR2NPC1MAPK1HPGDKDM4E | |
| SCHEMBL4473374 | 0.88 | DDR2 (0.54) | LCLAT1DDR2KMT2AMEN1NPC1 | |
| SCHEMBL9103475 | 0.85 | RAF1 (0.37) | MAPTKDR | |
| SCHEMBL9100193 | 0.82 | CDK8 (0.42) | DDR2KMT2AMEN1MAPK1POLB | |
| SCHEMBL9103231 | 0.82 | KDR (0.42) | KMT2AMEN1KDR | |
| SCHEMBL9100020 | 0.81 | RAF1 (0.55) | DDR2MAPK1KDM4EL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685125-B1 | Pyrrole derivatives useful for the treatment of proliferative diseases | MERCK PATENT GMBH (DE) | 2012-06-06 | — | — | EP | claimed |