Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.73 |
| ▸ | GLA | P06280 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | UBE2N | P61088 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 4/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2855888 | 0.95 | HSD17B10 (0.70) | HSD17B10GLAALDH1A1MAPTUBE2N | |
| SCHEMBL2858296 | 0.86 | ALDH1A1 (0.69) | HSD17B10GLAALDH1A1KDM4EMAPK1 | |
| SCHEMBL2861650 | 0.86 | ALDH1A1 (0.69) | HSD17B10GLAALDH1A1KDM4EMAPK1 | |
| SCHEMBL2867374 | 0.86 | ALDH1A1 (0.69) | HSD17B10GLAALDH1A1KDM4EMAPK1 | |
| SCHEMBL2859662 | 0.85 | ALDH1A1 (0.68) | HSD17B10GLAALDH1A1MAPTUBE2N | |
| SCHEMBL2855808 | 0.81 | ALDH1A1 (0.65) | HSD17B10GLAALDH1A1KDM4EMAPK1 | |
| SCHEMBL2864602 | 0.81 | LMNA (0.58) | HSD17B10GLAALDH1A1MAPTKDM4E | |
| SCHEMBL2863203 | 0.81 | ALDH1A1 (0.61) | HSD17B10GLAALDH1A1KDM4EMAPK1 | |
| SCHEMBL2861596 | 0.79 | ALDH1A1 (0.63) | HSD17B10GLAALDH1A1MAPTKDM4E | |
| SCHEMBL2861611 | 0.79 | ALDH1A1 (0.63) | HSD17B10GLAALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2239257-B1 | NOVEL QUINAZOLINE-2,4-DIONE DERIVATIVE, AND MEDICAL COMPOSITIONS FOR THE PROPHYLAXIS AND TREATMENT OF CRANIAL NERVE DISEASE CONTAINING THE SAME | SHIN POONG PHARMACEUTICAL CO LTD (KR) | 2012-06-06 | — | — | EP | claimed |