Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 4/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.40 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.30 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.30 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9107656 | 0.92 | GHSR (0.41) | GHSRAGTR1XIAPMAPTTP53 | |
| SCHEMBL9107917 | 0.92 | GHSR (0.45) | GHSRAGTR1XIAPMAPTTP53 | |
| SCHEMBL9107707 | 0.91 | GHSR (0.41) | GHSRAGTR1XIAPMAPTTP53 | |
| SCHEMBL9104201 | 0.90 | GHSR (0.48) | GHSRAGTR1XIAP | |
| SCHEMBL9108780 | 0.85 | GHSR (0.42) | GHSRAGTR1XIAPMAPTTP53 | |
| SCHEMBL9102835 | 0.85 | GHSR (0.48) | GHSRAGTR1XIAPMAPTTP53 | |
| SCHEMBL9103746 | 0.84 | GHSR (0.49) | GHSRAGTR1XIAPMAPTTP53 | |
| SCHEMBL9105693 | 0.84 | GHSR (0.44) | GHSRAGTR1XIAP | |
| SCHEMBL9106874 | 0.84 | GHSR (0.49) | GHSRAGTR1XIAPMAPTTP53 | |
| SCHEMBL9105861 | 0.83 | GHSR (0.58) | GHSRAGTR1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995003290-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-02-02 | — | — | WO | claimed |
| US-5430144-A | E.g, N-(1-((2'-((methoxycarbonyl)amino)(1,1'-biphenyl)-4-yl) methyl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl)-3 ((fur-2-yl)methyl)amino-3-methylbutanamide | MERCK & CO., INC. (US) | 1995-07-04 | — | — | US | disclosed |
| WO-1995003290-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-02-02 | — | — | WO | disclosed |