Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | PIK3C2G | O75747 | 3/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9100124 | 0.85 | NR1H2 (0.40) | PIK3CDPIK3C2GPIK3CGAURKAAURKB | |
| SCHEMBL9101244 | 0.81 | CASP1 (0.45) | PIK3CDPIK3C2GPIK3CGAURKAAURKB | |
| SCHEMBL9100099 | 0.80 | RAF1 (0.32) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL9101978 | 0.80 | MAPT (0.53) | MAPTLMNASMN1; SMN2POLBMEN1 | |
| SCHEMBL9004267 | 0.79 | NR1H2 (0.47) | PIK3CDPIK3C2GPIK3CGAURKAAURKB | |
| SCHEMBL9101169 | 0.72 | NR1H2 (0.38) | PIK3CDPIK3C2GPIK3CGAURKAAURKB | |
| SCHEMBL9097611 | 0.71 | MAPT (0.36) | MAPTLMNASMN1; SMN2POLB | |
| SCHEMBL9101666 | 0.71 | MAPT (0.34) | MAPTLMNASMN1; SMN2POLB | |
| SCHEMBL17975298 | 0.69 | NR1H2 (0.45) | PIK3CDPIK3C2GPIK3CGAURKAAURKB | |
| SCHEMBL9927344 | 0.67 | NISCH (0.36) | NR1H2NR1H3MAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5550122-A | INHIBIT REVERSE TRANSCRIPTASE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1996-08-27 | — | — | US | claimed |
| EP-0415303-B1 | Pyrido [2,3-b][1,5]benzoxazepin (and thiazepin)-5(6H)-ones and -thiones and their use in the prevention or treatment of HIV infection | BOEHRINGER INGELHEIM PHARMA (US) | 1995-12-13 | — | — | EP | claimed |
| EP-0415303-A2 | Pyrido [2,3-b][1,5]benzoxazepin (and thiazepin)-5(6H)-ones and -thiones and their use in the prevention or treatment of HIV infection | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1991-03-06 | — | — | EP | claimed |
| JP-4178390-A | — | — | None | — | — | JP | disclosed |
| US-5550122-A | INHIBIT REVERSE TRANSCRIPTASE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1996-08-27 | — | — | US | disclosed |
| EP-0415303-B1 | Pyrido [2,3-b][1,5]benzoxazepin (and thiazepin)-5(6H)-ones and -thiones and their use in the prevention or treatment of HIV infection | BOEHRINGER INGELHEIM PHARMA (US) | 1995-12-13 | — | — | EP | disclosed |
| JP-H04178390-A | PYRIDO(2,3-B)(1,5)BENZOXAZEPIN (AND THIAZEPIN)-5(6H)-ONES AND THIONES AND PHARMACEUTICAL FORMULATOR CONTAING THEM FOR PROPHYLANIS AND TREATMENT OF HIV INFECTIOUS DISEASE | BOEHRINGER INGELHEIM PHARMACEUT INC | 1992-06-25 | — | — | JP | disclosed |
| EP-0415303-A2 | Pyrido [2,3-b][1,5]benzoxazepin (and thiazepin)-5(6H)-ones and -thiones and their use in the prevention or treatment of HIV infection | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1991-03-06 | — | — | EP | disclosed |