Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9103467 | 1.00 | KMT2A (0.41) | KMT2ASMN1; SMN2LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL10067851 | 0.83 | L3MBTL1 (0.37) | KMT2ASMN1; SMN2L3MBTL1ALDH1A1GAA | |
| SCHEMBL2141753 | 0.82 | EPHX2 (0.42) | KMT2AALDH1A1AAK1MEN1NPC1 | |
| SCHEMBL3775975 | 0.78 | NPC1 (0.41) | KMT2ASMN1; SMN2LMNAALDH1A1AAK1 | |
| SCHEMBL8421394 | 0.74 | MAPT (0.41) | KMT2ASMN1; SMN2LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL3819101 | 0.74 | RAB9A (0.47) | KMT2ASMN1; SMN2ALDH1A1GAAMAPT | |
| SCHEMBL8423235 | 0.74 | MAPT (0.41) | KMT2ASMN1; SMN2LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL27559407 | 0.74 | MEN1 (0.43) | KMT2ASMN1; SMN2LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL25321456 | 0.74 | AAK1 (0.58) | KMT2ASMN1; SMN2ALDH1A1AAK1TDP1 | |
| SCHEMBL3781586 | 0.73 | AAK1 (0.52) | KMT2ASMN1; SMN2ALDH1A1GAAAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8487104-B2 | KAT II inhibitors | PFIZER INC. (US) | 2013-07-16 | — | — | US | disclosed |
| US-20120142729-A1 | KAT ll INHIBITORS | PFIZER INC. | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142729-A1 | KAT ll INHIBITORS | KAT7, KAT2A, KATNA1 | KMT2A 68/4885SMN1; SMN2 3322/4885LMNA 3207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.