Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 3/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9104116 | 1.00 | CYP3A4 (0.46) | CYP3A4MAPTTHRBMAPK1PDE4A | |
| SCHEMBL5265250 | 0.86 | MAPT (0.47) | CYP3A4MAPTTHRBMAPK1PDE4A | |
| SCHEMBL9100097 | 0.80 | STING1 (0.51) | CYP3A4MAPTAPPBACE1KDM4E | |
| SCHEMBL9100087 | 0.80 | STING1 (0.51) | CYP3A4MAPTAPPBACE1KDM4E | |
| SCHEMBL9106609 | 0.80 | STING1 (0.51) | CYP3A4MAPTAPPBACE1KDM4E | |
| SCHEMBL9100105 | 0.80 | STING1 (0.51) | CYP3A4MAPTAPPBACE1KDM4E | |
| SCHEMBL9106612 | 0.80 | STING1 (0.51) | CYP3A4MAPTAPPBACE1KDM4E | |
| SCHEMBL5113999 | 0.79 | PDE4A (0.40) | MAPTMAPK1PDE4APDE4BPDE4C | |
| SCHEMBL24983638 | 0.79 | CYP3A4 (0.50) | CYP3A4MAPTMAPK1APPHIF1A | |
| SCHEMBL13507373 | 0.79 | CYP3A4 (0.50) | CYP3A4MAPTMAPK1APPHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160068503-A1 | (-)-EPIGALLOCATECHIN GALLATE DERIVATIVES FOR INHIBITING PROTEASOME | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2016-03-10 | — | — | US | disclosed |
| US-8710248-B2 | (−)-epigallocatechin gallate derivatives for inhibiting proteasome | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2014-04-29 | — | — | US | disclosed |
| US-20120232135-A1 | (-)-Epigallocatechin Gallate Derivatives for Inhibiting Proteasome | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2012-09-13 | — | — | US | disclosed |
| US-8193377-B2 | (−)-epigallocatechin gallate derivatives for inhibiting proteasome | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2012-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232135-A1 | (-)-Epigallocatechin Gallate Derivatives for Inhibiting Proteasome | PSMC1, PSME1, PSMB1 | CYP3A4 3777/4885MAPT 2132/4885THRB 3400/4885 |
| US-20160068503-A1 | (-)-EPIGALLOCATECHIN GALLATE DERIVATIVES FOR INHIBITING PROTEASOME | PSMC1, PSME1, PSMB1 | CYP3A4 3777/4885MAPT 2132/4885THRB 3400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.