Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 3/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6670685 | 0.88 | CYP3A4 (0.41) | MAPTCYP3A4MAPK1THRBPDE4A | |
| SCHEMBL5268319 | 0.86 | PDE4A (0.38) | MAPTCYP3A4MAPK1THRBPDE4A | |
| SCHEMBL9104116 | 0.86 | CYP3A4 (0.46) | MAPTCYP3A4MAPK1THRBPDE4A | |
| SCHEMBL9103638 | 0.86 | CYP3A4 (0.46) | MAPTCYP3A4MAPK1THRBPDE4A | |
| SCHEMBL6671389 | 0.83 | BACE1 (0.40) | MAPTCYP3A4MAPK1THRBPDE4A | |
| SCHEMBL5264345 | 0.81 | PDE4A (0.37) | MAPTCYP3A4MAPK1THRBPDE4A | |
| SCHEMBL5620025 | 0.80 | SIRT1 (0.40) | MAPTCYP3A4MAPK1THRBPDE4A | |
| SCHEMBL24983638 | 0.80 | CYP3A4 (0.50) | MAPTCYP3A4MAPK1APPHIF1A | |
| SCHEMBL13507373 | 0.80 | CYP3A4 (0.50) | MAPTCYP3A4MAPK1APPHIF1A | |
| SCHEMBL13507688 | 0.80 | CYP3A4 (0.50) | MAPTCYP3A4MAPK1APPHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070276147-A1 | Synthesis of Oligomeric Epicatechin- and Catechin-Derived Procyanidins | KOZIKOWSKI ALAN P | 2007-11-29 | — | — | US | claimed |
| US-6849746-B2 | Synthetic methods for polyphenols | MARS, INC. (US) | 2005-02-01 | — | — | US | claimed |
| JP-2004508362-A | — | — | 2004-03-18 | — | — | JP | claimed |
| EP-1317437-A2 | SYNTHESIS OF 4-ALPHA-ARYLEPICATECHINS | Mars Incorporated (US) | 2003-06-11 | — | — | EP | claimed |
| US-20030100775-A1 | Synthesis of 4alpha-arylepicatechins | MARS INCORPORATED | 2003-05-29 | — | — | US | claimed |
| WO-2002020506-A2 | SYNTHESIS OF 4α-ARYLEPICATECHINS | MARS, INCORPORATED (US) | 2002-03-14 | — | — | WO | claimed |
| EP-1317437-B1 | SYNTHESIS OF 4-ALPHA-ARYLEPICATECHINS | MARS INC (US) | 2007-10-03 | — | — | EP | disclosed |
| US-7268240-B2 | Synthetic methods for polyphenols | MARS, INC. | 2007-09-11 | — | — | US | disclosed |
| US-20070197804-A1 | Synthesis of 4alpha-arylepicatechins | MARS, INCORPORATED | 2007-08-23 | — | — | US | disclosed |
| US-7126014-B2 | Synthesis of epecatechin-4α, 8-epicatechin and -catechin dimers and derivatives thereof | MARS, INC. | 2006-10-24 | — | — | US | disclosed |
| US-6849746-B2 | Synthetic methods for polyphenols | MARS, INC. (US) | 2005-02-01 | — | — | US | disclosed |
| US-20050014958-A1 | Synthesis of 4alpha-arylepicatechins | MARS, INCORPORATED | 2005-01-20 | — | — | US | disclosed |
| US-20040235941-A1 | Dimer digallate compositions | MARS, INCORPORATED | 2004-11-25 | — | — | US | disclosed |
| WO-2002020506-A2 | SYNTHESIS OF 4α-ARYLEPICATECHINS | MARS, INCORPORATED (US) | 2002-03-14 | — | — | WO | disclosed |
| EP-1169304-A1 | 8-8, 6-6 AND 6-8 CATECHIN AND EPICATECHIN DIMERS AND METHODS FOR THEIR PREPARATION | Mars Incorporated (US) | 2002-01-09 | — | — | EP | disclosed |
| US-6207842-B1 | FROM EPICATECHIN | MARS INCORPORATED | 2001-03-27 | — | — | US | disclosed |
| US-6156912-A | 88, 66, and 68 catechin and epicatechin dimers and methods for their preparation | MARS, INCORPORATED (US) | 2000-12-05 | — | — | US | disclosed |
| WO-2000061547-A1 | 8-8, 6-6 AND 6-8 CATECHIN AND EPICATECHIN DIMERS AND METHODS FOR THEIR PREPARATION | MARS, INCORPORATED (US) | 2000-10-19 | — | — | WO | disclosed |
| EP-1027345-A1 | SYNTHETIC METHODS FOR POLYPHENOLS | Mars Incorporated (US) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999019319-A1 | SYNTHETIC METHODS FOR POLYPHENOLS | MARS INCORPORATED (US) | 1999-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100775-A1 | Synthesis of 4alpha-arylepicatechins | FABP4, TEAD4, FABP7 | MAPT 2148/4885CYP3A4 300/4885MAPK1 2923/4885 |
| US-20050014958-A1 | Synthesis of 4alpha-arylepicatechins | FABP7, FABP4, TEAD4 | MAPT 1948/4885CYP3A4 463/4885MAPK1 2997/4885 |
| US-20040235941-A1 | Dimer digallate compositions | NOD2, GID4, GPX4 | MAPT 1853/4885CYP3A4 304/4885MAPK1 2879/4885 |
| US-20070197804-A1 | Synthesis of 4alpha-arylepicatechins | FABP7, FABP4, TEAD4 | MAPT 1948/4885CYP3A4 463/4885MAPK1 2997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.