Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 14/20 | 0.57 |
| ▸ | CA1 | P00915 | 11/20 | 0.57 |
| ▸ | CA6 | P23280 | 3/20 | 0.57 |
| ▸ | CA4 | P22748 | 2/20 | 0.57 |
| ▸ | CA9 | Q16790 | 8/20 | 0.42 |
| ▸ | CA5A | P35218 | 4/20 | 0.42 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA7 | P43166 | 3/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28161501 | 0.81 | CA1 (0.39) | CA2CA1CA6CA4CDK2 | |
| SCHEMBL14918216 | 0.78 | ALDH1A1 (0.39) | CA2CA1CA6CA4PLCG1 | |
| SCHEMBL2557830 | 0.76 | CDK2 (0.42) | CA2CA1CA6CA4CA9 | |
| SCHEMBL8480118 | 0.75 | CA2 (0.61) | CA2CA1CA6CA4CA9 | |
| SCHEMBL31370840 | 0.75 | CA2 (0.61) | CA2CA1CA6CA4CA9 | |
| SCHEMBL16012994 | 0.74 | CA1 (0.41) | CA2CA1CA6CA4CA9 | |
| SCHEMBL528641 | 0.74 | CA2 (0.67) | CA2CA1CA6CA4CA9 | |
| SCHEMBL9321209 | 0.74 | ALDH1A1 (0.50) | CA2CA1CA6CA4CA9 | |
| SCHEMBL30630011 | 0.73 | CA2 (1.00) | CA2CA1CA6CA4CA9 | |
| SCHEMBL344271 | 0.73 | CA2 (1.00) | CA2CA1CA6CA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434261-A | Benzo-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1995-07-18 | — | — | US | disclosed |
| WO-1995003289-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-02-02 | — | — | WO | disclosed |