Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.43 |
| ▸ | KDR | P35968 | 8/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | MARK3 | P27448 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5611567 | 0.90 | MAPK14 (0.47) | BRAFKDREPHB4TEKRIPK1 | |
| SCHEMBL9885318 | 0.90 | KDR (0.55) | BRAFKDR | |
| Cyclopropane SCHEMBL9104865 | 0.89 | KDR (0.45) | BRAFKDREPHB4TEKPTGER3 | |
| SCHEMBL5959715 | 0.89 | KDR (0.44) | BRAFKDREPHB4TEKRIPK1 | |
| SCHEMBL5586125 | 0.88 | KDR (0.42) | BRAFKDREPHB4TEKRIPK1 | |
| SCHEMBL5959843 | 0.87 | KDR (0.43) | BRAFKDREPHB4TEKRIPK1 | |
| SCHEMBL5592775 | 0.86 | RIPK1 (0.49) | BRAFKDREPHB4TEKRIPK1 | |
| SCHEMBL5612386 | 0.86 | KDR (0.45) | BRAFKDREPHB4TEKRIPK1 | |
| SCHEMBL5586037 | 0.85 | RIPK1 (0.46) | BRAFKDREPHB4TEKRIPK1 | |
| SCHEMBL5612143 | 0.85 | EPHB4 (0.52) | BRAFKDREPHB4TEKRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858879-B1 | 1,3-DIARYL SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT INC (US) | 2012-06-06 | — | — | EP | claimed |