Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 4/20 | 0.44 |
| ▸ | GHSR | Q92847 | 2/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 9/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 9/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 7/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.41 |
| ▸ | PTGFR | P43088 | 3/20 | 0.41 |
| ▸ | PTGIR | P43119 | 3/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9109495 | 0.95 | AGTR1 (0.44) | AGTR1GHSRPTGER1PTGER3PTGER4 | |
| SCHEMBL9102870 | 0.92 | AGTR1 (0.45) | AGTR1GHSRPTGER1PTGER3PTGER4 | |
| SCHEMBL9106412 | 0.92 | GHSR (0.44) | AGTR1GHSRPTGER1PTGER3PTGER4 | |
| SCHEMBL9105733 | 0.91 | GHSR (0.52) | AGTR1GHSRPTGER1PTGER3PTGER4 | |
| SCHEMBL9106037 | 0.91 | AGTR1 (0.44) | AGTR1GHSRPTGER1PTGER3PTGER4 | |
| SCHEMBL9105244 | 0.91 | AGTR1 (0.44) | AGTR1GHSRPTGER1PTGER3PTGER4 | |
| SCHEMBL9103745 | 0.91 | GHSR (0.44) | AGTR1GHSRPTGER1PTGER3PTGER4 | |
| SCHEMBL9103376 | 0.90 | GHSR (0.47) | AGTR1GHSRPTGER1PTGER3PTGER4 | |
| SCHEMBL9106416 | 0.89 | GHSR (0.55) | AGTR1GHSRPTGER1PTGER3PTGER4 | |
| SCHEMBL9108223 | 0.86 | AGTR1 (0.45) | AGTR1GHSRPTGER1PTGER3PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434261-A | Benzo-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1995-07-18 | — | — | US | disclosed |
| WO-1995003289-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-02-02 | — | — | WO | disclosed |