Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 6/20 | 0.62 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | F2R | P25116 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1095326 | 0.86 | NLRP3 (0.61) | NLRP3KDM4EPOLBGLALMNA | |
| SCHEMBL27887951 | 0.85 | NLRP3 (0.47) | NLRP3CLCN2KDM4EPOLBGLA | |
| SCHEMBL11520630 | 0.84 | KDM4E (0.55) | NLRP3KDM4EPOLBGLALMNA | |
| SCHEMBL11624236 | 0.84 | NLRP3 (0.63) | NLRP3KDM4EPOLBGLALMNA | |
| SCHEMBL27862720 | 0.80 | NLRP3 (0.53) | NLRP3KDM4EPOLBGLALMNA | |
| SCHEMBL27661779 | 0.77 | CLCN2 (0.63) | CLCN2KDM4EPOLBLMNAMAPT | |
| SCHEMBL20703086 | 0.77 | NLRP3 (1.00) | NLRP3KDM4EPOLBGLALMNA | |
| SCHEMBL10489819 | 0.76 | KMT2A (0.63) | KDM4EPOLBLMNAMAPTHSD17B10 | |
| SCHEMBL8657991 | 0.76 | ALDH1A1 (0.56) | NLRP3KDM4EPOLBLMNAMAPT | |
| SCHEMBL10489851 | 0.76 | ALDH1A1 (0.56) | NLRP3CLCN2KDM4EPOLBGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2239257-B1 | NOVEL QUINAZOLINE-2,4-DIONE DERIVATIVE, AND MEDICAL COMPOSITIONS FOR THE PROPHYLAXIS AND TREATMENT OF CRANIAL NERVE DISEASE CONTAINING THE SAME | SHIN POONG PHARMACEUTICAL CO LTD (KR) | 2012-06-06 | — | — | EP | claimed |
| US-4952573-A | FOR CONTROLLING TISSUE STABILITY DURING EYE SURGERY; ANTISWELLING AGENT | LABORATOIRS ALCON S.A. (FR) | 1990-08-28 | — | — | US | disclosed |