Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.34 |
| ▸ | DHFR | P00374 | 6/20 | 0.33 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | HEXA | P06865 | 1/20 | 0.31 |
| ▸ | HEXB | P07686 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL512514 | 0.91 | NOS1 (0.40) | NOS1HRH3HRH2FGFR1FGFR2 | |
| SCHEMBL513286 | 0.81 | HRH3 (0.41) | NOS1HRH3HRH2FGFR1FGFR2 | |
| SCHEMBL512977 | 0.74 | NOS1 (0.38) | NOS1HRH3HRH2FGFR1FGFR2 | |
| SCHEMBL1226812 | 0.70 | DHFR (0.35) | HRH3HRH2HRH4DHFR | |
| SCHEMBL513417 | 0.68 | NOS1 (0.40) | NOS1HRH3HRH2FGFR1FGFR2 | |
| SCHEMBL513386 | 0.67 | HRH4 (0.50) | NOS1HRH3HRH2FGFR1FGFR2 | |
| SCHEMBL513416 | 0.66 | NOS1 (0.38) | NOS1HRH3HRH2DHFRDCPS | |
| SCHEMBL512761 | 0.65 | NOS1 (0.37) | NOS1HRH3HRH2FGFR1FGFR2 | |
| SCHEMBL512760 | 0.64 | NOS1 (0.36) | NOS1HRH3HRH2DHFRDCPS | |
| SCHEMBL8634425 | 0.60 | NOS1 (0.38) | NOS1HRH3HRH2DHFRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459197-A1 | COMPOUNDS FOR THE REDUCTION OF -AMYLOID PRODUCTION | Bristol-Myers Squibb Company (US) | 2012-06-06 | — | — | EP | claimed |