Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | VDR | P11473 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9107544 | 0.81 | GAA (0.41) | MEN1KMT2AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL21816259 | 0.68 | DPP4 (0.45) | MEN1KMT2AKDM4EKDM5AKDM4C | |
| SCHEMBL7660371 | 0.67 | DPP4 (0.41) | MEN1KMT2AKDM4EKDM5AKDM4C | |
| SCHEMBL27158579 | 0.66 | ALDH1A1 (0.52) | MEN1KMT2AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL12817477 | 0.66 | KDM5A (0.44) | KDM4EKDM5AKDM4CSMN1; SMN2ALDH1A1 | |
| SCHEMBL311734 | 0.65 | SMN1; SMN2 (0.43) | KDM4ELMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL518596 | 0.65 | BRD4 (0.46) | KDM4ETP53LMNASMN1; SMN2GAA | |
| SCHEMBL27953621 | 0.64 | HCAR3 (0.41) | KDM4EGAAALDH1A1MAPT | |
| SCHEMBL31713567 | 0.63 | SMN1; SMN2 (0.48) | KDM4EKDM5AKDM4CLMNASMN1; SMN2 | |
| SCHEMBL392396 | 0.63 | SMN1; SMN2 (0.48) | KDM4EKDM5AKDM4CLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8816085-B2 | Methylpyrrolopyridinecarboxamides | TAKEDA GMBH (DE) | 2014-08-26 | — | — | US | disclosed |
| US-20120142633-A1 | METHYLPYRROLOPYRIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142633-A1 | METHYLPYRROLOPYRIDINECARBOXAMIDES | PDE5A, PDE3A, PDE2A | MEN1 2045/4885KMT2A 1463/4885ATM 3058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.