Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.49 |
| ▸ | PGK1 | P00558 | 1/20 | 0.47 |
| ▸ | PGK2 | P07205 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butane SCHEMBL4025883 | 0.93 | FDPS (0.44) | FDPSPGK1PGK2KDM4EALDH1A1 | |
| SCHEMBL17915603 | 0.81 | GBA1 (0.43) | FDPSKDM4EALDH1A1GBA1MEN1 | |
| SCHEMBL14769117 | 0.78 | PGK1 (0.48) | PGK1PGK2 | |
| SCHEMBL28327869 | 0.78 | FDPS (0.42) | FDPSKDM4EALDH1A1GBA1MEN1 | |
| SCHEMBL14769151 | 0.77 | PGK1 (0.47) | PGK1PGK2CA12MMP2 | |
| SCHEMBL14769201 | 0.77 | PGK1 (0.47) | PGK1PGK2KDM4ERAB9A | |
| Hydrochloric Acid SCHEMBL2637290 | 0.76 | PGK1 (0.46) | FDPSPGK1PGK2CA12 | |
| SCHEMBL1106224 | 0.74 | GBA1 (0.41) | FDPSKDM4EALDH1A1GBA1RAB9A | |
| SCHEMBL30563036 | 0.74 | GBA1 (0.41) | FDPSKDM4EALDH1A1GBA1RAB9A | |
| SCHEMBL14769155 | 0.73 | PGK1 (0.47) | PGK1PGK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3035929-B1 | 7A-AMIDE SUBSTITUTED-6,6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES | MERCK SHARP & DOHME LLC (US) | 2024-07-03 | — | — | EP | disclosed |
| EP-3035928-B1 | 3'-PYRIDYL SUBSTITUTED- 6,6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES | MERCK SHARP & DOHME LLC (US) | 2023-10-18 | — | — | EP | disclosed |
| US-10322140-B2 | Preparation and use of 7a-heterocycle substituted-6,6-difluoro bicyclic himbacine derivatives as PAR-1 receptor antagonists | MERCK SHARP & DOHME CORP. | 2019-06-18 | — | — | US | disclosed |
| US-20180015106-A1 | PREPARATION AND USE OF 7A-HETEROCYCLE SUBSTITUTED- 6,6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES AS PAR-1 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-01-18 | — | — | US | disclosed |
| US-9808473-B2 | Preparation and use of 3-pyridyl substituted-6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2017-11-07 | — | — | US | disclosed |
| US-20170240539-A1 | Preparation and Use of Cyclic Sulfonamide Derivatives as PAR-1 Receptor Antagonists | MERCK SHARP & DOHME CORP. (US) | 2017-08-24 | — | — | US | disclosed |
| EP-3206687-A1 | PREPARATION AND USE OF CYCLIC SULFONAMIDE DERIVATIVES AS PAR-1 RECEPTOR ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2017-08-23 | — | — | EP | disclosed |
| US-9701669-B2 | Preparation and use of 7a-amide substituted- 6,6-difluoro bicyclic himbacine derivatives as PAR-1 receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2017-07-11 | — | — | US | disclosed |
| US-20160200713-A1 | PREPARATION AND USE OF 3-PYRIDYL SUBSTITUTED- 6,6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES AS PAR-1 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-07-14 | — | — | US | disclosed |
| US-20160185764-A1 | PREPARATION AND USE OF 7A-AMIDE SUBSTITUTED- 6,6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES AS PAR-1 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-06-30 | — | — | US | disclosed |
| EP-3035929-A1 | 7A-AMIDE SUBSTITUTED-6,6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2016-06-29 | — | — | EP | disclosed |
| EP-3035928-A1 | 3'-PYRIDYL SUBSTITUTED- 6,6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2016-06-29 | — | — | EP | disclosed |
| EP-3035930-A1 | 7A-HETEROCYCLE SUBSTITUTED- 6, 6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2016-06-29 | — | — | EP | disclosed |
| WO-2016060940-A1 | PREPARATION AND USE OF CYCLIC SULFONAMIDE DERIVATIVES AS PAR-1 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-04-21 | — | — | WO | disclosed |
| WO-2015026685-A1 | 7A-HETEROCYCLE SUBSTITUTED- 6, 6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2015-02-26 | — | — | WO | disclosed |
| WO-2015026686-A1 | 3'-PYRIDYL SUBSTITUTED- 6,6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2015-02-26 | — | — | WO | disclosed |
| WO-2015026693-A1 | 7A-AMIDE SUBSTITUTED-6,6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2015-02-26 | — | — | WO | disclosed |
| US-20120142690-A1 | Substituted piperidines | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10322140-B2 | Preparation and use of 7a-heterocycle substituted-6,6-difluoro bicyclic himbacine derivatives as PAR-1 receptor antagonists | F2R, F2RL1, BDKRB1 | FDPS 2802/4885PGK1 3515/4885PGK2 4304/4885 |
| US-20160185764-A1 | PREPARATION AND USE OF 7A-AMIDE SUBSTITUTED- 6,6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES AS PAR-1 RECEPTOR ANTAGONISTS | F2R, F2RL1, BDKRB1 | FDPS 4441/4885PGK1 4501/4885PGK2 4792/4885 |
| US-20160200713-A1 | PREPARATION AND USE OF 3-PYRIDYL SUBSTITUTED- 6,6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES AS PAR-1 RECEPTOR ANTAGONISTS | F2R, F2RL1, F2RL3 | FDPS 3012/4885PGK1 3573/4885PGK2 4253/4885 |
| US-20180015106-A1 | PREPARATION AND USE OF 7A-HETEROCYCLE SUBSTITUTED- 6,6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES AS PAR-1 RECEPTOR ANTAGONISTS | F2R, F2RL1, BDKRB1 | FDPS 2802/4885PGK1 3515/4885PGK2 4304/4885 |
| US-20120142690-A1 | Substituted piperidines | VHL, PIR, PIGO | FDPS 313/4885PGK1 1216/4885PGK2 835/4885 |
| US-20170240539-A1 | Preparation and Use of Cyclic Sulfonamide Derivatives as PAR-1 Receptor Antagonists | F2R, PRSS1, F2RL1 | FDPS 2295/4885PGK1 2590/4885PGK2 2848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.