⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2105209 | 0.78 | ADRA2A (0.38) | — | |
| Medetomidine SCHEMBL787913 | 0.76 | ADRA2A (0.50) | — | |
| Dexmedetomidine SCHEMBL12092460 | 0.76 | ADRA2A (0.50) | — | |
| Dexmedetomidine SCHEMBL119382 | 0.76 | ADRA2A (0.50) | — | |
| Medetomidine SCHEMBL18497244 | 0.76 | ADRA2A (0.50) | — | |
| Medetomidine SCHEMBL26432 | 0.76 | ADRA2A (0.50) | — | |
| Dexmedetomidine SCHEMBL29431568 | 0.76 | ADRA2A (0.50) | — | |
| Dexmedetomidine SCHEMBL14861666 | 0.76 | ADRA2A (0.50) | — | |
| Medetomidine SCHEMBL22616139 | 0.75 | ADRA2A (0.49) | — | |
| Dexmedetomidine SCHEMBL22476079 | 0.75 | ADRA2A (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795154-A1 | PHARMACEUTICAL COMPOSITION COMPRISING (S)-(3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL)METHANOL FOR USE IN TREATING OCULAR CONDITIONS | Allergan, Inc. (US) | 2021-03-24 | — | — | EP | disclosed |
| EP-3093017-B1 | PHARMACEUTICAL COMPOSITION COMPRISING (S)-(3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL)METHANOL FOR TREATING OPTIC NEUROPATHY | ALLERGAN INC (US) | 2021-01-06 | — | — | EP | disclosed |
| CN-105412092-B | Ester prodrugs of [3- (1- (1H-imidazol-4-yl) ethyl) -2-methylphenyl ] methanol for lowering intraocular pressure | 阿勒根公司 | 2020-11-17 | — | — | CN | disclosed |
| EP-3698789-A1 | ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL] METHANOL FOR LOWERING INTRAOCULAR PRESSURE | ALLERGAN, INC. (US) | 2020-08-26 | — | — | EP | disclosed |
| EP-3636263-A1 | ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL] METHANOL | ALLERGAN, INC. (US) | 2020-04-15 | — | — | EP | disclosed |
| EP-3348264-A1 | ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL] METHANOL FOR LOWERING INTRAOCULAR PRESSURE | ALLERGAN, INC. (US) | 2018-07-18 | — | — | EP | disclosed |
| EP-3053576-B1 | ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL] METHANOL FOR LOWERING INTRAOCULAR PRESSURE | ALLERGAN INC (US) | 2018-05-16 | — | — | EP | disclosed |
| EP-3050563-B1 | ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL] METHANOL FOR TREATING SKIN DISEASES AND CONDITIONS | ALLERGAN INC (US) | 2018-05-09 | — | — | EP | disclosed |
| EP-3093017-A1 | PHARMACEUTICAL COMPOSITION COMPRISING (S)-(3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL)METHANOL FOR USE IN TREATING MAMMALIAN CONDITIONS | ALLERGAN, INC. (US) | 2016-11-16 | — | — | EP | disclosed |
| EP-3053576-A1 | ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL] METHANOL FOR LOWERING INTRAOCULAR PRESSURE | ALLERGAN, INC. (US) | 2016-08-10 | — | — | EP | disclosed |
| EP-3050563-A1 | ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL] METHANOL FOR TREATING SKIN DISEASES AND CONDITIONS | ALLERGAN, INC. (US) | 2016-08-03 | — | — | EP | disclosed |
| EP-2616067-B1 | ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL]METHANOL FOR TREATING SKIN DISEASES AND CONDITIONS | ALLERGAN INC (US) | 2016-05-18 | — | — | EP | disclosed |
| EP-2616069-A1 | ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL]METHANOL | Allergan, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| EP-2616068-A1 | ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL]METHANOL FOR LOWERING INTRAOCULAR PRESSURE | Allergan, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| US-20120142746-A1 | ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL] METHANOL FOR LOWERING INTRAOCULAR PRESSURE | ALLERGAN, INC. (US) | 2012-06-07 | — | — | US | disclosed |
| WO-2012037499-A1 | ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL] METHANOL | ALLERGAN, INC. (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037490-A1 | ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL] METHANOL FOR LOWERING INTRAOCULAR PRESSURE | ALLERGAN, INC. (US) | 2012-03-22 | — | — | WO | disclosed |