SCHEMBL9106801

SCHEMBL9106801

Cc1ccc(CC(C(=O)O)c2cncc(Cl)c2)cc1C

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
P4HTM Q9NXG6 1/20 0.39
CNR1 P21554 1/20 0.38
CPB2 Q96IY4 2/20 0.38
CPB1 P15086 1/20 0.38
PSMB8 P28062 2/20 0.37
PSMB5 P28074 2/20 0.37
CCR2 P41597 1/20 0.37
S1PR1 P21453 1/20 0.36
CTSB P07858 1/20 0.36
PPARG P37231 4/20 0.36
PPARA Q07869 3/20 0.36
PTGES O14684 1/20 0.36
HCAR2 Q8TDS4 1/20 0.36
CCNC P24863 1/20 0.34
CDK8 P49336 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
CPA1 P15085 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9109224 0.82 CYP2C9 (0.50) CNR1PSMB8PSMB5CCR2PPARG
SCHEMBL9101178 0.82 MEN1 (0.52) PSMB8PSMB5CCR2S1PR1CTSB
SCHEMBL9109575 0.80 P4HTM (0.50) P4HTMCNR1CPB2CPB1PSMB8
SCHEMBL14276998 0.78 CTSB (0.50) P4HTMPSMB8PSMB5CTSBPPARG
SCHEMBL9108574 0.78 CTSB (0.50) P4HTMPSMB8PSMB5CTSBPPARG
SCHEMBL27668092 0.75 ESR1 (0.44) P4HTMHCAR2CPA1
SCHEMBL9100514 0.74 PSMB5 (0.40) P4HTMPSMB8PSMB5S1PR1CTSB
SCHEMBL16751962 0.74 HCAR2 (0.42) PPARGPPARAHCAR2CYP2C9CYP2C19
SCHEMBL9104789 0.73 CTSB (0.44) P4HTMCPB2PSMB8PSMB5CTSB
SCHEMBL9110899 0.72 LDHA (0.53) PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2646024-B1 NOVEL BENZYL AZETIDINE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS ALLERGAN INC (US) 2014-10-22 EP disclosed
EP-2646027-B1 NOVEL PYRIDINE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS ALLERGAN INC (US) 2014-10-15 EP disclosed
US-20140213573-A1 NOVEL BENZYL AZETIDINE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS ALLERGAN, INC. (US) 2014-07-31 US disclosed
US-20140128369-A1 NOVEL BENZYL AZETIDINE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS ALLERGAN, INC. (US) 2014-05-08 US disclosed
US-8697733-B2 Pyridine derivatives as sphingosine 1-phosphate (S1P) receptor modulators ALLERGAN, INC. (US) 2014-04-15 US disclosed
US-20130338195-A1 NOVEL PYRIDINE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS ALLERGAN, INC. 2013-12-19 US disclosed
US-8492410-B2 Pyridine derivatives as sphingosine 1-phosphate (S1P) receptor modulators ALLERGAN, INC. (US) 2013-07-23 US disclosed
US-20130150411-A1 NOVEL PYRIDINE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS ALLERGAN, INC. (US) 2013-06-13 US disclosed
US-8399492-B2 Pyridine derivatives as sphingosine 1-phosphate (S1P) receptor modulators ALLERGAN, INC. (US) 2013-03-19 US disclosed
US-20120142736-A1 NOVEL PYRIDINE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS ALLERGAN, INC. (US) 2012-06-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130150411-A1 NOVEL PYRIDINE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS S1PR1, S1PR3, S1PR2 P4HTM 2314/4885CNR1 11/4885CPB2 3963/4885
US-20130338195-A1 NOVEL PYRIDINE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS S1PR1, S1PR3, S1PR2 P4HTM 2314/4885CNR1 11/4885CPB2 3963/4885
US-20140213573-A1 NOVEL BENZYL AZETIDINE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS S1PR1, S1PR2, S1PR5 P4HTM 2439/4885CNR1 22/4885CPB2 4018/4885
US-20120142736-A1 NOVEL PYRIDINE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS S1PR1, S1PR3, S1PR2 P4HTM 2314/4885CNR1 11/4885CPB2 3963/4885
US-20140128369-A1 NOVEL BENZYL AZETIDINE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS S1PR1, S1PR2, S1PR5 P4HTM 2439/4885CNR1 22/4885CPB2 4018/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.