Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 12/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 3/20 | 0.37 |
| ▸ | CASP7 | P55210 | 3/20 | 0.37 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9103369 | 0.94 | CCNT1 (0.46) | KDM5AKDM4CCDK9CCNT1 | |
| SCHEMBL9101829 | 0.89 | MAPT (0.38) | MEN1KMT2AHPGDMAPK1NPSR1 | |
| SCHEMBL9105395 | 0.88 | CCNT1 (0.41) | KDM4CCDK9CCNT1LMNA | |
| SCHEMBL9896342 | 0.87 | KDM5A (0.40) | KDM5AKDM4CCDK9CCNT1TSHR | |
| SCHEMBL9105094 | 0.86 | KDM2B (0.43) | KDM4CCDK9CCNT1MEN1KMT2A | |
| SCHEMBL9107121 | 0.84 | LMNA (0.40) | CDK9CCNT1MEN1KMT2AHPGD | |
| SCHEMBL9106061 | 0.83 | CDK9 (0.43) | KDM5AKDM4CCDK9CCNT1CDK1 | |
| SCHEMBL9107702 | 0.83 | CDK9 (0.43) | KDM5AKDM4CCDK9CCNT1CDK1 | |
| SCHEMBL9106078 | 0.83 | CDK9 (0.43) | KDM5AKDM4CCDK9CCNT1CDK1 | |
| SCHEMBL9105958 | 0.83 | CDK9 (0.41) | KDM5AKDM4CCDK9CCNT1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8816085-B2 | Methylpyrrolopyridinecarboxamides | TAKEDA GMBH (DE) | 2014-08-26 | — | — | US | disclosed |
| US-20120142633-A1 | METHYLPYRROLOPYRIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142633-A1 | METHYLPYRROLOPYRIDINECARBOXAMIDES | PDE5A, PDE3A, PDE2A | KDM5A 65/4885KDM4C 134/4885CDK9 1048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.