Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.59 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12511 | 0.98 | UBE2T (0.61) | UBE2TASIC3SMN1; SMN2ALOX15HTT | |
| Hydrogen Sulfide SCHEMBL23045115 | 0.96 | UBE2T (0.59) | UBE2TASIC3SMN1; SMN2ALOX15HTT | |
| SCHEMBL2034241 | 0.87 | SMN1; SMN2 (0.62) | UBE2TASIC3SMN1; SMN2ALOX15HTT | |
| Iodide SCHEMBL8930200 | 0.86 | ALOX15 (0.57) | UBE2TASIC3SMN1; SMN2ALOX15HTT | |
| SCHEMBL19372016 | 0.86 | UBE2T (0.70) | UBE2TASIC3SMN1; SMN2ALOX15HTT | |
| SCHEMBL31173766 | 0.86 | ALOX15 (0.60) | UBE2TASIC3SMN1; SMN2ALOX15HTT | |
| Benzene SCHEMBL28273759 | 0.86 | SMN1; SMN2 (0.65) | UBE2TASIC3SMN1; SMN2ALOX15HTT | |
| SCHEMBL175532 | 0.86 | ALOX15 (0.60) | UBE2TASIC3SMN1; SMN2ALOX15HTT | |
| Iodide SCHEMBL9450324 | 0.85 | UBE2T (0.63) | UBE2TASIC3SMN1; SMN2ALOX15HTT | |
| SCHEMBL11596488 | 0.84 | ALOX15 (0.59) | UBE2TASIC3SMN1; SMN2ALOX15HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459733-A2 | NOVEL PEPTIDASE SUBSTRATES | Biomérieux (FR) | 2012-06-06 | — | — | EP | disclosed |