Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.37 |
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 2/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9106014 | 1.00 | P2RX7 (0.40) | P2RX7TSHRPHGDHHDAC1HDAC6 | |
| SCHEMBL9101928 | 0.87 | P2RX7 (0.44) | P2RX7TSHRPHGDHHDAC1HDAC6 | |
| SCHEMBL9101917 | 0.87 | P2RX7 (0.44) | P2RX7TSHRPHGDHHDAC1HDAC6 | |
| SCHEMBL9106744 | 0.86 | TSHR (0.52) | P2RX7TSHRPHGDHHDAC1HDAC6 | |
| SCHEMBL9106736 | 0.86 | TSHR (0.52) | P2RX7TSHRPHGDHHDAC1HDAC6 | |
| SCHEMBL9109207 | 0.81 | CCR1 (0.47) | P2RX7TSHRPHGDHHDAC1HDAC6 | |
| SCHEMBL9109215 | 0.81 | CCR1 (0.47) | P2RX7TSHRPHGDHHDAC1HDAC6 | |
| SCHEMBL9108816 | 0.81 | P2RX7 (0.47) | P2RX7TSHRPHGDHHDAC1HDAC6 | |
| SCHEMBL13285326 | 0.81 | TSHR (0.45) | P2RX7TSHRPHGDHHDAC1HDAC6 | |
| SCHEMBL9108825 | 0.81 | P2RX7 (0.47) | P2RX7TSHRPHGDHHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2384320-B1 | PYRROLIDINE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INT (DE) | 2015-03-04 | — | — | EP | disclosed |
| US-8629157-B2 | Pyrrolidine compounds which modulate the CB2 receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-14 | — | — | US | disclosed |
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | CNR2, CNR1, OPRL1 | P2RX7 26/4885TSHR 1003/4885PHGDH 3135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.