⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20167702 | 0.76 | — | — | |
| SCHEMBL20167671 | 0.76 | — | — | |
| SCHEMBL20167673 | 0.76 | — | — | |
| SCHEMBL17590181 | 0.73 | — | — | |
| SCHEMBL331115 | 0.72 | — | — | |
| SCHEMBL28366364 | 0.70 | TRPA1 (0.65) | — | |
| SCHEMBL30350978 | 0.69 | TRPA1 (0.65) | — | |
| SCHEMBL1021266 | 0.69 | — | — | |
| SCHEMBL9282879 | 0.69 | — | — | |
| SCHEMBL4094838 | 0.68 | LMNA (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646445-B1 | OXAZOLO[5,4-B]PYRIDIN-5-YL COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2016-03-16 | — | — | EP | disclosed |
| EP-2646445-A1 | OXAZOLO [5, 4 -B]PYRIDIN- 5 -YL COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | Eli Lilly and Company (US) | 2013-10-09 | — | — | EP | disclosed |
| US-8288548-B2 | Oxazolo[5-4-b]pyridin-5-yl compounds | ELI LILLY AND COMPANY (US) | 2012-10-16 | — | — | US | disclosed |
| US-20120142724-A1 | OXAZOLO[5-4-b]PYRIDIN-5-YL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2012-06-07 | — | — | US | disclosed |
| WO-2012074761-A1 | OXAZOLO [5, 4 -B] PYRIDIN- 5 -YL COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | ELI LILLY AND COMPANY (US) | 2012-06-07 | — | — | WO | disclosed |