⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17210714 | 0.79 | DNM1 (0.38) | — | |
| SCHEMBL10050128 | 0.75 | — | — | |
| SCHEMBL11126725 | 0.75 | — | — | |
| SCHEMBL29173088 | 0.73 | — | — | |
| SCHEMBL9750691 | 0.73 | — | — | |
| SCHEMBL21123053 | 0.72 | — | — | |
| SCHEMBL17514073 | 0.71 | — | — | |
| SCHEMBL16588372 | 0.71 | — | — | |
| SCHEMBL19480772 | 0.67 | — | — | |
| SCHEMBL29314837 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130053618-A1 | RADIATION SENSITIVE LIPOSOMES | VARIAN MEDICAL SYSTEMS, INC. (US) | 2013-02-28 | — | — | US | disclosed |
| US-8128942-B2 | Anti-sepsis conjugate vaccine | ENDOBIOLOGICS, INCORPORATED (US) | 2012-03-06 | — | — | US | disclosed |
| US-20110027307-A1 | ANTI-SEPSIS CONJUGATE VACCINE | ENDOBIOLOGICS, INCORPORATED (US) | 2011-02-03 | — | — | US | disclosed |
| US-20090042973-A1 | Inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED | 2009-02-12 | — | — | US | disclosed |
| US-7442718-B2 | Inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-10-28 | — | — | US | disclosed |