Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.46 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.46 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.46 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.46 |
| ▸ | CBFB | Q13951 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9110493 | 0.86 | HTT (0.47) | CYP1A2CYP2C19NPSR1HTTSMN1; SMN2 | |
| SCHEMBL18622117 | 0.84 | ALDH1A1 (0.49) | CYP1A2HTTSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL3981200 | 0.83 | KMT2A (0.45) | HTTSMN1; SMN2L3MBTL1ALDH1A1MAPT | |
| SCHEMBL11201221 | 0.81 | ALDH1A1 (0.43) | CYP1A2CYP2C19NPSR1HTTSMN1; SMN2 | |
| SCHEMBL14496257 | 0.78 | HTT (0.50) | CYP1A2CYP2C19NPSR1HTTSMN1; SMN2 | |
| SCHEMBL11639262 | 0.77 | ALDH1A1 (0.58) | CYP1A2HTTSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL31725340 | 0.76 | KMT2A (0.65) | NPSR1HTTSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL8716883 | 0.76 | KMT2A (0.65) | NPSR1HTTSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL11417747 | 0.76 | SMN1; SMN2 (0.59) | CYP1A2HTTSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL3026745 | 0.76 | HSD17B10 (0.53) | CYP1A2CYP2C19NPSR1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0670831-A1 | QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-09-13 | — | — | EP | disclosed |
| WO-1995009159-A1 | QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1995-04-06 | — | — | WO | disclosed |