Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.83 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.83 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.83 |
| ▸ | CHRNB3 | Q05901 | 3/20 | 0.83 |
| ▸ | CHRNA6 | Q15825 | 3/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CHKA | P35790 | 1/20 | 0.48 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22672736 | 0.98 | CHRNB2 (0.80) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| Ammonia Solution, Strong SCHEMBL27973853 | 0.98 | CHRNB2 (0.80) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| SCHEMBL4630620 | 0.98 | CHRNB2 (0.80) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| SCHEMBL22672737 | 0.98 | CHRNB2 (0.80) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| SCHEMBL7787652 | 0.98 | CHRNB2 (0.80) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| SCHEMBL930742 | 0.98 | CHRNB2 (0.80) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| SCHEMBL22672738 | 0.98 | CHRNB2 (0.80) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| Hydrochloric Acid SCHEMBL2248932 | 0.96 | CHRNB2 (0.77) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| SCHEMBL911817 | 0.96 | CHRNB2 (0.83) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| SCHEMBL8314 | 0.91 | CHRNB2 (1.00) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 143 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11168084-B2 | Purine based compounds as toll-like receptor 9 antagonist | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2021-11-09 | — | — | US | claimed |
| EP-3707140-B1 | PURINE BASED COMPOUNDS AS TOLL-LIKE RECEPTOR 9 ANTAGONISTS | COUNCIL SCIENT IND RES (IN) | 2021-10-13 | — | — | EP | claimed |
| US-20200347062-A1 | PURINE BASED COMPOUNDS AS TOLL-LIKE RECEPTOR 9 ANTAGONIST | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2020-11-05 | — | — | US | claimed |
| EP-3707140-A1 | PURINE BASED COMPOUNDS AS TOLL-LIKE RECEPTOR 9 ANTAGONIST | Council of Scientific and Industrial Research (IN) | 2020-09-16 | — | — | EP | claimed |
| WO-2025101892-A1 | POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS AND USES THEREOF | Astellas Engineered Small Molecules US, Incorporated (US) | 2025-05-15 | — | — | WO | disclosed |
| WO-2025082731-A1 | INTRANASAL FORMULATIONS FOR TREATING OBSTRUCTIVE SLEEP APNEA | MOSANNA THERAPEUTICS AG (CH) | 2025-04-24 | — | — | WO | disclosed |
| CN-119143715-B | Diaryl methylpiperazine compound and preparation method, pharmaceutical composition and application thereof | 天津匠新致成科技有限公司 | 2025-03-14 | — | — | CN | disclosed |
| EP-4479138-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | Accent Therapeutics, Inc. (US) | 2024-12-25 | — | — | EP | disclosed |
| CN-119143715-A | Diaryl methylpiperazine compound and preparation method, pharmaceutical composition and application thereof | 天津匠新致成科技有限公司 | 2024-12-17 | — | — | CN | disclosed |
| EP-3969450-B1 | QUINAZOLINE-2,4-DIONE DERIVATIVES AS PARP INHIBITORS | SUZHOU FOUR HEALTH PHARMACEUTICALS CO LTD (CN) | 2023-10-25 | — | — | EP | disclosed |
| WO-2023154519-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |
| CN-113636970-B | Isoindolone compound, preparation method and application thereof | 河北康泰药业有限公司 | 2023-05-23 | — | — | CN | disclosed |
| US-6262059-B1 | Method of treating a patient having precancerous lesions with quinazoline derivatives | CELL PATHWAYS, INC. | 2001-07-17 | — | — | US | disclosed |
| US-6235747-B1 | NITRIC OXIDE SYNTHASE INHIBITOR | PFIZER INC. | 2001-05-22 | — | — | US | disclosed |
| CN-1215391-A | 6-phenylpyridyl-2-amine derivatives | PFIZER (US) | 1999-04-28 | — | — | CN | disclosed |
| EP-0891332-A1 | 6-PHENYLPYRIDYL-2-AMINE DERIVATIVES | PFIZER INC. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036871-A1 | 6-PHENYLPYRIDYL-2-AMINE DERIVATIVES | PFIZER INC. (US) | 1997-10-09 | — | — | WO | disclosed |
| WO-1979000166-A1 | CYANOCARBOXAMIDINES AND QUINAZOLINE PROCESS | BRISTOL MYERS CO (US) | 1979-04-05 | — | — | WO | disclosed |
| US-4138561-A | Cyanocarboxamidines and quinazoline process | BRISTOL-MYERS COMPANY (US) | 1979-02-06 | — | — | US | disclosed |
| US-4060615-A | ANTIHYPERTENSIVE, PHOSPHODIESTERASE INHIBITOR | MEAD JOHNSON & COMPANY (US) | 1977-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11168084-B2 | Purine based compounds as toll-like receptor 9 antagonist | TLR9, TLR1, TLR7 | CHRNB2 2830/4885CHRNA3 2792/4885CHRNA4 2420/4885 |
| US-20200347062-A1 | PURINE BASED COMPOUNDS AS TOLL-LIKE RECEPTOR 9 ANTAGONIST | TLR9, TLR1, TLR7 | CHRNB2 2714/4885CHRNA3 2711/4885CHRNA4 2349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.