Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 11/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16511856 | 0.93 | NR1H4 (0.49) | GPBAR1PRKCDNR1H4 | |
| SCHEMBL9891265 | 0.91 | GPBAR1 (0.56) | GPBAR1PRKCD | |
| SCHEMBL9891336 | 0.90 | GPBAR1 (0.57) | GPBAR1PRKCD | |
| SCHEMBL18525840 | 0.89 | — | — | |
| SCHEMBL15918674 | 0.89 | — | — | |
| SCHEMBL15947500 | 0.89 | — | — | |
| SCHEMBL9108376 | 0.89 | NR1H4 (0.50) | GPBAR1NR1H4 | |
| SCHEMBL15947454 | 0.89 | NR1H4 (0.50) | GPBAR1NR1H4 | |
| SCHEMBL15933732 | 0.88 | — | — | |
| SCHEMBL12698029 | 0.88 | GPBAR1 (0.50) | GPBAR1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920090-B2 | Betulinic acid derivatives with HIV maturation inhibitory activity | VIIV Healthcare UK (No.5) Limited (GB) | 2018-03-20 | — | — | US | disclosed |
| US-20170204133-A1 | BETULINIC ACID DERIVATIVES WITH HIV MATURATION INHIBITORY ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY | 2017-07-20 | — | — | US | disclosed |
| EP-2576586-B1 | C-28 AMIDES OF MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2015-08-12 | — | — | EP | disclosed |
| US-8802661-B2 | C-28 amides of modified C-3 betulinic acid derivatives as HIV maturation inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-08-12 | — | — | US | disclosed |
| US-20120142653-A1 | C-28 AMIDES OF MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-06-07 | — | — | US | disclosed |
| WO-2011153319-A1 | C-28 AMIDES OF MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142653-A1 | C-28 AMIDES OF MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS | ERG28, BET1, BRD3 | GPBAR1 2177/4885PRKCD 2347/4885NR1H4 2324/4885 |
| US-20170204133-A1 | BETULINIC ACID DERIVATIVES WITH HIV MATURATION INHIBITORY ACTIVITY | BET1, PGGT1B, TMPO | GPBAR1 1377/4885PRKCD 4019/4885NR1H4 2291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.