Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | CDK9 | P50750 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.52 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.51 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.51 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17533119 | 0.83 | MAPK1 (0.58) | SMN1; SMN2ALDH1A1ADORA3HTTLMNA | |
| SCHEMBL4772885 | 0.80 | POLB (0.59) | SMN1; SMN2TSHRTP53EPHX1EPHX2 | |
| SCHEMBL14498671 | 0.79 | TSHR (0.49) | SMN1; SMN2TSHRTP53EPHX1EPHX2 | |
| SCHEMBL7346662 | 0.78 | ALDH1A1 (0.55) | SMN1; SMN2TSHRALDH1A1HTTLMNA | |
| SCHEMBL8507647 | 0.77 | GAA (0.59) | SMN1; SMN2TSHRALDH1A1HTTLMNA | |
| SCHEMBL14498648 | 0.76 | TSHR (0.46) | SMN1; SMN2TSHRTP53EPHX1EPHX2 | |
| SCHEMBL18292654 | 0.75 | GAA (0.64) | SMN1; SMN2TSHRALDH1A1HTTLMNA | |
| Diphenylurea SCHEMBL133103 | 0.72 | SMN1; SMN2 (1.00) | SMN1; SMN2TSHRTP53EPHX1EPHX2 | |
| SCHEMBL14590428 | 0.72 | ALDH1A1 (0.60) | SMN1; SMN2TSHRALDH1A1HTTLMNA | |
| SCHEMBL14937204 | 0.72 | ALDH1A1 (0.60) | SMN1; SMN2TSHRALDH1A1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995014679-A1 | TETRAZOLE-SUBSTITUTED UREA ACAT INHIBITORS | PARKE, DAVIS & COMPANY (US) | 1995-06-01 | — | — | WO | disclosed |
| US-5362744-A | Treatnent of athrosclerosis, anticholesterol agents | WARNER-LAMBERT COMPANY (US) | 1994-11-08 | — | — | US | disclosed |
| US-5073565-A | Atherosclerosis, anticholesterol | WARNER-LAMBERT COMPANY (US) | 1991-12-17 | — | — | US | disclosed |
| WO-1991017150-A1 | TETRAZOLE UREA AND THIOUREA ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1991-11-14 | — | — | WO | disclosed |