Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27926380 | 0.83 | FEN1 (0.53) | FEN1ALDH1A1HPGDAKR1B1NPC1 | |
| SCHEMBL27521668 | 0.82 | ALDH1A1 (0.41) | FEN1ALDH1A1HPGDAKR1B1NPC1 | |
| SCHEMBL12431212 | 0.79 | FEN1 (0.59) | FEN1ALDH1A1HPGDAKR1B1NPC1 | |
| SCHEMBL3138030 | 0.77 | FEN1 (0.57) | FEN1ALDH1A1HPGDAKR1B1NPC1 | |
| SCHEMBL8239577 | 0.77 | FEN1 (0.57) | FEN1ALDH1A1HPGDAKR1B1NPC1 | |
| SCHEMBL169401 | 0.77 | FEN1 (0.57) | FEN1ALDH1A1HPGDAKR1B1NPC1 | |
| SCHEMBL4869850 | 0.77 | FEN1 (0.57) | FEN1ALDH1A1HPGDAKR1B1NPC1 | |
| SCHEMBL27946190 | 0.77 | ALDH1A1 (0.56) | FEN1ALDH1A1HPGDAKR1B1NPC1 | |
| SCHEMBL28166467 | 0.76 | FEN1 (0.71) | FEN1ALDH1A1HPGDAKR1B1KMT2A | |
| SCHEMBL5546213 | 0.76 | ERCC5 (0.58) | FEN1ALDH1A1HPGDNPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1114834-A | antidiabetic agent | OTSUKA PHARMA CO LTD (JP) | 1996-01-10 | — | — | CN | disclosed |
| EP-0670831-A1 | QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-09-13 | — | — | EP | disclosed |
| WO-1995009159-A1 | QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1995-04-06 | — | — | WO | disclosed |