Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 3/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 6/20 | 0.49 |
| ▸ | BACE1 | P56817 | 6/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | KIF5B | P33176 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8647403 | 0.84 | EGFR (0.61) | EGFRCSF1RHTR7PDE10AHTR1A | |
| SCHEMBL27477800 | 0.84 | EGFR (0.60) | EGFRCSF1RHTR7PDE10AHTR1A | |
| SCHEMBL8647902 | 0.81 | EGFR (0.55) | EGFRCSF1RHTR7PDE10AHTR1A | |
| Lithium Ion SCHEMBL8650898 | 0.81 | EGFR (0.55) | EGFRCSF1RHTR7PDE10AHTR1A | |
| SCHEMBL8650896 | 0.81 | EGFR (0.55) | EGFRCSF1RHTR7PDE10AHTR1A | |
| Lithium SCHEMBL8650904 | 0.81 | EGFR (0.55) | EGFRCSF1RHTR7PDE10AHTR1A | |
| SCHEMBL4718427 | 0.78 | EGFR (0.65) | EGFRCSF1RHTR7PDE10AHTR1A | |
| Hydrochloric Acid SCHEMBL6181670 | 0.77 | EGFR (0.66) | EGFRCSF1RHTR7PDE10AHTR1A | |
| SCHEMBL4399739 | 0.74 | HTR7 (0.53) | EGFRCSF1RHTR7PDE10AHTR1A | |
| SCHEMBL5468434 | 0.73 | ACHE (0.68) | EGFRCSF1RHTR7PDE10AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1141633-A | 4-heterocyclic substituted quinazoline derivatives, process for their preparation and their use as anticancer agents | PFIZER (US) | 1997-01-29 | — | — | CN | disclosed |
| WO-1995023141-A1 | 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS | PFIZER INC. (US) | 1995-08-31 | — | — | WO | disclosed |