Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 3/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2009244 | 0.80 | GPR3 (0.44) | GPR3TGFBR1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL13134221 | 0.80 | GPR3 (0.44) | GPR3TGFBR1CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL2491044 | 0.76 | MAPT (0.44) | GPR3ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL10738298 | 0.76 | HPGD (0.42) | GPR3TGFBR1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL2491042 | 0.76 | MAPT (0.44) | GPR3ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL10738301 | 0.76 | HPGD (0.42) | GPR3TGFBR1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL10843177 | 0.75 | NPC1 (0.37) | GPR3TGFBR1CYP1A2CYP2C19ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10842837 | 0.74 | HPGD (0.41) | GPR3TGFBR1CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL9111565 | 0.74 | GPR3 (0.39) | GPR3TGFBR1CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL436407 | 0.72 | GPR3 (0.50) | GPR3TGFBR1CYP1A2CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1114834-A | antidiabetic agent | OTSUKA PHARMA CO LTD (JP) | 1996-01-10 | — | — | CN | disclosed |
| US-5459142-A | Autoimmune disease, atherosclerosis, antiischemic agents and nephritis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0670831-A1 | QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-09-13 | — | — | EP | disclosed |
| WO-1995009159-A1 | QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1995-04-06 | — | — | WO | disclosed |